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TTF2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.{{cite journal | vauthors = Liu M, Xie Z, Price DH | title = A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member | journal = The Journal of Biological Chemistry | volume = 273 | issue = 40 | pages = 25541–4 | date = October 1998 | pmid = 9748214 | doi = 10.1074/jbc.273.40.25541 | doi-access = free }}{{cite web | title = Entrez Gene: TTF2 transcription termination factor, RNA polymerase II| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8458}}

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.

Interactions

TTF2 has been shown to interact with CDC5L.{{cite journal | vauthors = Leonard D, Ajuh P, Lamond AI, Legerski RJ | title = hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 4 | pages = 793–801 | date = September 2003 | pmid = 12927788 | doi = 10.1016/S0006-291X(03)01486-4 | citeseerx = 10.1.1.539.8359 }}

References

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Further reading

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  • {{cite journal | vauthors = Girdham CH, Glover DM | title = Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein | journal = Genes & Development | volume = 5 | issue = 10 | pages = 1786–99 | date = October 1991 | pmid = 1916263 | doi = 10.1101/gad.5.10.1786 | doi-access = free }}
  • {{cite journal | vauthors = Hara R, Selby CP, Liu M, Price DH, Sancar A | title = Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer | journal = The Journal of Biological Chemistry | volume = 274 | issue = 35 | pages = 24779–86 | date = August 1999 | pmid = 10455150 | doi = 10.1074/jbc.274.35.24779 | doi-access = free }}
  • {{cite journal | vauthors = Leonard D, Ajuh P, Lamond AI, Legerski RJ | title = hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing | journal = Biochemical and Biophysical Research Communications | volume = 308 | issue = 4 | pages = 793–801 | date = September 2003 | pmid = 12927788 | doi = 10.1016/S0006-291X(03)01486-4 | citeseerx = 10.1.1.539.8359 }}
  • {{cite journal | vauthors = Jiang Y, Liu M, Spencer CA, Price DH | title = Involvement of transcription termination factor 2 in mitotic repression of transcription elongation | journal = Molecular Cell | volume = 14 | issue = 3 | pages = 375–85 | date = May 2004 | pmid = 15125840 | doi = 10.1016/S1097-2765(04)00234-5 | doi-access = free }}
  • {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
  • {{cite journal | vauthors = Jiang Y, Price DH | title = Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector | journal = Cell Cycle | volume = 3 | issue = 9 | pages = 1151–3 | date = September 2004 | pmid = 15467445 | doi = 10.4161/cc.3.9.1151 | doi-access = free }}

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