TTI2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans.
{{cite web
| title = Entrez Gene: TELO2 interacting protein 2
| url = https://www.ncbi.nlm.nih.gov/gene/80185
| access-date = 2016-12-14
}}
Function
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.
The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.
References
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Further reading
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- {{cite journal |vauthors=Hurov KE, Cotta-Ramusino C, Elledge SJ |title=A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability |journal=Genes Dev. |volume=24 |issue=17 |pages=1939–50 |year=2010 |pmid=20810650 |pmc=2932975 |doi=10.1101/gad.1934210 }}
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