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TUSC2

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Tumor suppressor candidate 2 is a protein that in humans is encoded by the TUSC2 gene.{{cite journal | vauthors = Fischer WH, Schubert D | title = Characterization of a novel platelet-derived growth factor-associated protein | journal = J Neurochem | volume = 66 | issue = 5 | pages = 2213–6 |date=Jan 1997 | pmid = 8780057 | doi =10.1046/j.1471-4159.1996.66052213.x | s2cid = 28782367 }}{{cite journal | vauthors = Kondo M, Ji L, Kamibayashi C, Tomizawa Y, Randle D, Sekido Y, Yokota J, Kashuba V, Zabarovsky E, Kuzmin I, Lerman M, Roth J, Minna JD | title = Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells | journal = Oncogene | volume = 20 | issue = 43 | pages = 6258–62 |date=Oct 2001 | pmid = 11593436 | doi = 10.1038/sj.onc.1204832 | doi-access = | s2cid = 24352259 }}{{cite web | title = Entrez Gene: TUSC2 tumor suppressor candidate 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11334}}

This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available.

References

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Further reading

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  • {{cite journal |vauthors=Prudkin L, Behrens C, Liu DD, etal |title=Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. |journal=Clin. Cancer Res. |volume=14 |issue= 1 |pages= 41–7 |year= 2008 |pmid= 18172250 |doi= 10.1158/1078-0432.CCR-07-1252 | pmc=2833352 }}
  • {{cite journal | vauthors=Lee DY, Deng Z, Wang CH, Yang BB |title=MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 51 |pages= 20350–5 |year= 2008 |pmid= 18077375 |doi= 10.1073/pnas.0706901104 | pmc=2154434 |doi-access=free }}
  • {{cite journal |vauthors=Lin J, Sun T, Ji L, etal |title=Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. |journal=Oncogene |volume=26 |issue= 49 |pages= 6989–96 |year= 2007 |pmid= 17486070 |doi= 10.1038/sj.onc.1210500 |pmc=3457636}}
  • {{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Uno F, Sasaki J, Nishizaki M, etal |title=Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells. |journal=Cancer Res. |volume=64 |issue= 9 |pages= 2969–76 |year= 2004 |pmid= 15126327 |doi=10.1158/0008-5472.CAN-03-3702 |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Lerman MI, Minna JD |title=The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 6116–33 |year= 2000 |pmid= 11085536 }}

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