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TUSC3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.{{cite journal | vauthors = MacGrogan D, Levy A, Bova GS, Isaacs WB, Bookstein R | title = Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22 | journal = Genomics | volume = 35 | issue = 1 | pages = 55–65 |date=Sep 1996 | pmid = 8661104 | doi = 10.1006/geno.1996.0322 | doi-access = free }}{{cite journal | vauthors = Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM | title = The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors | journal = Proc Natl Acad Sci U S A | volume = 96 | issue = 7 | pages = 3928–33 |date=May 1999 | pmid = 10097140 | pmc = 22397 | doi =10.1073/pnas.96.7.3928 | bibcode = 1999PNAS...96.3928I | doi-access = free }}{{cite web | title = Entrez Gene: TUSC3 tumor suppressor candidate 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7991}}

This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.

References

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Further reading

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  • {{cite journal |vauthors=Pak BJ, Park H, Chang ER, etal |title=Differential display analysis of oxygen-mediated changes in gene expression in first trimester human trophoblast cells |journal=Placenta |volume=19 |issue= 7 |pages= 483–8 |year= 1998 |pmid= 9778121 |doi=10.1016/S0143-4004(98)91041-4 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R |title=Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties |journal=Mol. Cell |volume=12 |issue= 1 |pages= 101–11 |year= 2003 |pmid= 12887896 |doi=10.1016/S1097-2765(03)00243-0 |doi-access=free }}
  • {{cite journal |vauthors=Anderson NL, Polanski M, Pieper R, etal |title=The human plasma proteome: a nonredundant list developed by combination of four separate sources |journal=Mol. Cell. Proteomics |volume=3 |issue= 4 |pages= 311–26 |year= 2004 |pmid= 14718574 |doi= 10.1074/mcp.M300127-MCP200 |doi-access= free }}
  • {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Shibatani T, David LL, McCormack AL, etal |title=Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits |journal=Biochemistry |volume=44 |issue= 16 |pages= 5982–92 |year= 2005 |pmid= 15835887 |doi= 10.1021/bi047328f }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Pils D, Horak P, Gleiss A, etal |title=Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival |journal=Cancer |volume=104 |issue= 11 |pages= 2417–29 |year= 2006 |pmid= 16270321 |doi= 10.1002/cncr.21538 |s2cid=26030376 |doi-access=free }}
  • {{cite journal |vauthors=Guervós MA, Marcos CA, Hermsen M, etal |title=Deletions of N33, STK11 and TP53 are involved in the development of lymph node metastasis in larynx and pharynx carcinomas |journal=Cell. Oncol. |volume=29 |issue= 4 |pages= 327–34 |year= 2007 |pmid= 17641416 |pmc=4618212 |doi= 10.1155/2007/635962|doi-access=free }}

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