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TWSG1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.{{cite journal | vauthors = Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS | title = Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling | journal = Nature | volume = 410 | issue = 6827 | pages = 475–8 |date=Mar 2001 | pmid = 11260715 | doi = 10.1038/35068572 | s2cid = 4392365 }}{{cite web | title = Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57045}} The protein is a binding protein for bone morphogenetic proteins, similar to Chordin.{{cite journal | vauthors=Oelgeschläger M, Larraín J, Geissert D, De Robertis EM |title=The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling. |journal=Nature |volume=405 |issue= 6788 |pages= 757–63 |year= 2000 |pmid= 10866189 |doi= 10.1038/35015500 | pmc=2292104 |bibcode=2000Natur.405..757O }} The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.{{cite journal |last1=Graf |first1=D. |last2=Timmons |first2=P. M. |last3=Hitchins |first3=M. |last4=Episkopou |first4=V. |last5=Moore |first5=G. |last6=Ito |first6=T. |last7=Fujiyama |first7=A. |last8=Fisher |first8=A. G. |last9=Merkenschlager |first9=M. |title=Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation |journal=Mammalian Genome |date=July 2001 |volume=12 |issue=7 |pages=554–560 |doi=10.1007/s0033501-0005-x |pmid=11420619 |s2cid=36371559 |url=https://pubmed.ncbi.nlm.nih.gov/11420619/ |access-date=6 March 2023 |issn=0938-8990}}

References

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Further reading

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  • {{cite journal |vauthors=Graf D, Nethisinghe S, Palmer DB, etal |title=The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. |journal=J. Exp. Med. |volume=196 |issue= 2 |pages= 163–71 |year= 2002 |pmid= 12119341 |doi=10.1084/jem.20020276 | pmc=2193926 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Zakin L, De Robertis EM |title=Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development. |journal=Development |volume=131 |issue= 2 |pages= 413–24 |year= 2004 |pmid= 14681194 |doi= 10.1242/dev.00946 |doi-access= free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Moreno M, Muñoz R, Aroca F, etal |title=Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway. |journal=EMBO J. |volume=24 |issue= 7 |pages= 1397–405 |year= 2005 |pmid= 15775969 |doi= 10.1038/sj.emboj.7600615 | pmc=1142540 }}
  • {{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }}
  • {{cite journal |vauthors=Tzachanis D, Li L, Lafuente EM, etal |title=Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. |journal=Blood |volume=109 |issue= 7 |pages= 2944–52 |year= 2007 |pmid= 17164348 |doi= 10.1182/blood-2006-03-006510 | pmc=1852213 }}

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Category:Developmental genes and proteins

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