TachoSil

{{Short description|Collagen sponge used in surgery}}

{{Use dmy dates|date=June 2020}}

{{Infobox drug

| type = combo

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| component1 = Fibrinogen

| class1 = Glycoprotein

| component2 = Thrombin

| class2 = Coagulation factor

| pronounce =

| tradename = Tachosil

| Drugs.com = {{Drugs.com|ppa|fibrin-sealant}}

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| DailyMedID = Tachosil

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| routes_of_administration = Epilesional

| ATC_prefix = B02

| ATC_suffix = BC30

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| legal_UK = POM

| legal_UK_comment = {{cite web | title=TachoSil sealant matrix - Summary of Product Characteristics (SmPC) | website=(emc) | date=31 January 2020 | url=https://www.medicines.org.uk/emc/product/119/smpc | access-date=9 July 2020 | archive-date=10 July 2020 | archive-url=https://web.archive.org/web/20200710030954/https://www.medicines.org.uk/emc/product/119/smpc | url-status=dead }}

| legal_US = Rx-only

| legal_US_comment = {{cite web | title=Tachosil- thrombin human and fibrinogen patch | website=DailyMed | date=16 February 2023 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=69e05cbe-615e-45af-ad7e-92e3650cafc8 | access-date=19 May 2023 | archive-date=19 May 2023 | archive-url=https://web.archive.org/web/20230519224801/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=69e05cbe-615e-45af-ad7e-92e3650cafc8 | url-status=live }}{{cite web | title=Tachosil- thrombin human and fibrinogen patch | website=DailyMed | date=2 November 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c324332-290f-413f-820c-8c9a971a2766 | access-date=19 May 2023 | archive-date=19 May 2023 | archive-url=https://web.archive.org/web/20230519224805/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c324332-290f-413f-820c-8c9a971a2766 | url-status=live }}

| legal_EU = Rx-only

| legal_EU_comment = {{cite web | title=TachoSil EPAR | website=European Medicines Agency (EMA) | date=17 September 2018 | url=https://www.ema.europa.eu/en/medicines/human/EPAR/tachosil | access-date=9 July 2020 | archive-date=13 July 2020 | archive-url=https://web.archive.org/web/20200713060551/https://www.ema.europa.eu/en/medicines/human/EPAR/tachosil | url-status=live }} Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

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| KEGG = D12591

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Tachosil is an equine collagen sponge coated with the human plasma-derived coagulation factors fibrinogen and thrombin.{{cite journal | vauthors = Colombo GL, Bettoni D, Di Matteo S, Grumi C, Molon C, Spinelli D, Mauro G, Tarozzo A, Bruno GM | display-authors = 6 | title = Economic and outcomes consequences of Tachosil: a systematic review | journal = Vascular Health and Risk Management | volume = 10 | issue = | pages = 569–75 | date = 2014 | pmid = 25246797 | pmc = 4166367 | doi = 10.2147/VHRM.S63199 | doi-access = free }} It is used during surgery to stop local bleeding on internal organs (hemostasis). Tachosil reacts upon contact with blood, other body fluids or saline to form a clot that glues it to the tissue surface.

Tachosil may cause an allergic reaction, thrombosis (blood clots), a blockage in the intestine when used during abdominal surgeries, the formation of scar tissue and foreign body granuloma (a type of inflammatory reaction).