Tachykinin receptor
{{Short description|InterPro Family}}
{{Pfam box
|InterPro=IPR001681
}}
{{protein
| Name = tachykinin receptor 1
| caption =
| image =
| width =
| HGNCid = 11526
| Symbol = TACR1
| AltSymbols = TAC1R
| EntrezGene = 6869
| OMIM = 162323
| RefSeq = NM_001058
| UniProt = P25103
| PDB =
| ECnumber =
| Chromosome = 2
| Arm = p
| Band = 13.1
| LocusSupplementaryData = -p12
}}
{{protein
| Name = tachykinin receptor 2
| caption =
| image =
| width =
| HGNCid = 11527
| Symbol = TACR2
| AltSymbols = TAC2R, NKNAR
| EntrezGene = 6865
| OMIM = 162321
| RefSeq = NM_001057
| UniProt = P21452
| PDB =
| ECnumber =
| Chromosome = 10
| Arm = q11
| Band = -q21
| LocusSupplementaryData =
}}
{{protein
| Name = tachykinin receptor 3
| caption =
| image =
| width =
| HGNCid = 11528
| Symbol = TACR3
| AltSymbols =
| EntrezGene = 6870
| OMIM = 162332
| RefSeq = NM_001059
| UniProt = P29371
| PDB =
| ECnumber =
| Chromosome = 4
| Arm = q
| Band = 25
| LocusSupplementaryData =
}}
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.{{Cite web|title=Aprepitant|url=https://bnf.nice.org.uk/drug/aprepitant.html|website=NICE|access-date=2020-05-10}}
Binding
The genes and receptor ligands are as follows:{{cite journal | vauthors = Maggi CA | title = The mammalian tachykinin receptors | journal = General Pharmacology | volume = 26 | issue = 5 | pages = 911–44 | date = September 1995 | pmid = 7557266 | doi = 10.1016/0306-3623(94)00292-U }}
| class="wikitable"
! Receptor !! Gene !! Preferred ligand | ||
| NK1 | {{Gene|TACR1}} | substance P |
| NK2 | {{Gene|TACR2}} | neurokinin A |
| NK3 | {{Gene|TACR3}} | neurokinin B |
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also
References
{{reflist}}
External links
- {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1354 | title = Tachykinin Receptors | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}
- {{MeshName|Tachykinin+Receptor}}
{{G protein-coupled receptors}}
{{Neuropeptide receptors}}
{{Neurokinin receptor modulators}}
Category:G protein-coupled receptors
Category:Molecular neuroscience
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