Talinolol

{{chembox

| Verifiedfields = changed

| Watchedfields = changed

| verifiedrevid = 444379759

| ImageFile=Talinolol.svg

| ImageSize = 300px

| ImageName = Chemical structure of talinolol

| IUPACName=(RS)-1-[4-[3-(tert-Butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea

| OtherNames=

|Section1={{Chembox Identifiers

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 3S82268BKG

| IUPHAR_ligand = 4664

| CASNo_Ref = {{cascite|correct|CAS}}

| CASNo=57460-41-0

| PubChem=68770

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 152067

| SMILES=CC(C)(C)NCC(COC1=CC=C(C=C1)NC(=O)NC2CCCCC2)O

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 62014

| InChI = 1/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25)

| InChIKey = MXFWWQICDIZSOA-UHFFFAOYAN

| StdInChI_Ref = {{stdinchicite|changed|chemspider}}

| StdInChI = 1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25)

| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}

| StdInChIKey = MXFWWQICDIZSOA-UHFFFAOYSA-N

}}

|Section2={{Chembox Properties

| C=20 | H=33 | N=3 | O=3

| Appearance=

| Density=

| MeltingPt=

| BoilingPt=

| Solubility=

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|Section6={{Chembox Pharmacology

| ATCCode_prefix = C07

| ATCCode_suffix = AB13

}}

|Section7={{Chembox Hazards

| MainHazards=

| FlashPt=

| AutoignitionPt =

}}

}}

Talinolol is a beta blocker.{{Cite journal

| last1 = Abmann | first1 = I.

| title = The actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction

| doi = 10.1185/03007999509110493

| journal = Current Medical Research and Opinion

| volume = 13

| issue = 6

| pages = 325–342

| year = 1995

| pmid = 8829891

| pmc =

}}

Stereochemistry

Talinolol contains a stereocenter and consists of two enantiomers. This is a racemate, i.e. a 1: 1 mixture of (R)- and the (S)-forms:F. v. Bruchhausen, G. Dannhardt, S. Ebel, A. W. Frahm, E. Hackenthal, U. Holzgrabe (Hrsg.): Hagers Handbuch der Pharmazeutischen Praxis: Band 9: Stoffe P-Z, Springer Verlag, Berlin, Aufl. 5, 2014, S. 767, {{ISBN|978-3-642-63389-8}}.

class="wikitable" style="text-align:center"
class="hintergrundfarbe6"

! colspan="2"| Enantiomers of talinolol

300 px
(R)-talinolol
CAS number: 71369-60-3

| 300 px
(S)-talinolol
CAS number: 71369-59-0

References