Talk:Progestogen (medication)

Hi-

I am curious about the source of data for the table added by Terrace4 on 8/13/05, reporting the activity of different progestins. Any information regarding the source of this data would be greatly appreciated- NLMV, 2:19, 6 March 2006

:I've seen this table before, about a year ago, and have been looking for it recently. Whn I find the source for it, I'll post it. In the meantime, anyone know a endocrinologist with some spare time? Pelargonium 08:51, 27 March 2007 (UTC)Pelargonium

::Moved unsourced (for over 2 years!) table added [http://en.wikipedia.org/w/index.php?title=Progestin&diff=prev&oldid=20919956 12:31, 13 August 2005] by Terrace4 to this Talk page:

::

Different progestins have different combinations of androgen (testosterone-like) activity and progesterone activity. If the activity of 1 mg of norethindrone is taken as the baseline, 1 mg of the other progestins have activities as follows: {{Fact|date=February 2007}}

border="1" cellpadding="5" cellspacing="0" align="center"

align="center" | Progestin | Progestational activity | Androgen activity

align="center" | norethindrone | 1 | 1

align="center" | norethindrone acetate | 1.2 | 1.6

align="center" | desogestrel | 9 | 3.4

align="center" | drospirenone | 1.5 | 0

align="center" | ethynodiol diacetate | 1.4 | 0.6

align="center" | norelgestromin | 1.3 | 1.9

align="center" | norgestimate | 1.3 | 1.9

align="center" | levonorgestrel | 5.3 | 8.3

align="center" | dl-norgestrel | 2.6 | 4.2

::69.208.163.83 04:33, 19 September 2007 (UTC)

I took these comments (left by 76.24.212.162 out of the article. -Fennec (はさばくのきつね) 02:34, 12 July 2008 (UTC)

• (This is not correct. The term progestins, like the terms gestagens and progestagens, refers to a class of hormones and synthetic compounds. They can be naturally occurring in the body, as is the case with progesterone, or they can be synthesized compounds, as is the case with the progestins found in some hormone replacement or contraceptives.)

:: I agree with Fennec for removing the IP-signed edit... the comment lacked citations, though technically I see where they were going (indicating that progesterone is progestinic, as are sythetics) Likewise, I have changed the opening of the article to include the term "progestinic":

"A progestin is a synthetic progestogen that has progestinic effects similar to progesterone."

:: (continued) so... yeah, I tried to tie the concept of progesterone being "progestinic" together with the term "progestin" which usually ends up describing synthetics --Kuzetsa (talk) 03:55, 10 October 2008 (UTC)

I don't particularly know the best way to cite a journal I don't have full access to, so I'm just going to post a link to it here. [http://dx.doi.org/10.1016/j.jsbmb.2005.08.015 The Journal of Steroid Biochemistry and Molecular Biology, article titled "Pregnancy, progesterone and progestins in relation to breast cancer risk"] (point being, just in case anyone asks why I'm reverting some recent IP-edits) --Kuzetsa (talk) 03:25, 10 October 2008 (UTC)

: Just noticed, the article already made a distinction between Progesterone and a Progestin...

"The many synthetic hormones that resulted are known as progestins."

: (continued) So... I reverted a recent contrary claim / IP-edit that said otherwise --Kuzetsa (talk) 03:47, 10 October 2008 (UTC)

I removed off-topic trivia paragraphs about Percy Lavon Julian and Adolf Butenandt [http://en.wikipedia.org/w/index.php?title=Progestin&diff=488640451 added] to the History section by longtime disruptive IP-hopping anonymous editor 71.123.25.175 (aka 141.149.208.54 / 71.123.29.191 / 71.182.123.65 / 71.123.17.215 / 71.182.107.102 / 70.16.52.193 / 70.16.61.75 / 71.182.100.111 / 71.240.244.35 / 71.123.31.25 / 71.240.247.110 / 70.16.49.248 / 71.182.108.43 / 71.182.98.194 / 71.182.111.225)
which included these WP:COPYVIOs:

His discoveries about the structure of sex hormones led to the synthesis of steroids like cortisone, and paved the way for the development of birth control pills.

taken from: Binder, David (January 19, 1995). "[http://www.nytimes.com/1995/01/19/obituaries/adolf-butenandt-is-dead-at-91-won-nobel-for-hormone-work.html?pagewanted=all Adolf Butenandt Is dead at 91; won Nobel for hormone work.]" The New York Times, p. B11:

His discoveries about the structure of sex hormones led to the synthesis of steroids like cortisone, and paved the way for the development of birth control pills.

and:

A one-pound package of progesterone synthesized from soybean stigmasterol was sent to the Upjohn company
under armed guard and valued at close to $70,000.
It was the first commercial shipment of a synthetic sex hormone produced anywhere in America.

taken from: Smith, Llewellyn M.; Lyons, Stephen (February 6, 2007). "[http://www.pbs.org/wgbh/nova/transcripts/3402_julian.html Forgotten Genius (Percy Julian) transcript.]" Nova, Boston: WGBH:

NARRATOR: In 1940, Julian sent
a one-pound package of progesterone to the Upjohn pharmaceutical company. Shipped
under armed guard and valued at nearly $70,000,
it was the first commercial shipment of an artificial sex hormone produced anywhere in America.

The Percy Lavon Julian, Progesterone, Soybean, Combined oral contraceptive pill, Hormonal contraception, and Carl Djerassi articles are currently semi-protected to protect them from similar persistent disruption by this IP-hopping anonymous editor edit warring across a series of articles adding off-topic Percy Lavon Julian trivia and WP:COPYVIOs against consensus without contributing to talk page discussions.
Lynn4 (talk) 19:47, 22 April 2012 (UTC)

Under strong exertion, I am wondoring iff the body can burn this substances. IF so, a heavily working woman would not be affected.

They are seemingly similar to... DIESEL components, benzpyrenes, etc.

So question is if inhaling diesel exhaust particles would have progesterone effects. Wikistallion (talk) 14:56, 24 July 2018 (UTC)

Question also ifallsimilar compounds are progesterone related, WHAT IS THE TOTAL ACCUMULATED DOSIS IF ALL SIMILAR COMPOUNDS IN Diesel exhaust or SMOKE? how about charcoal smoke that occurs in Africa containing benzpyrene etc? Wikistallion (talk) 15:12, 24 July 2018 (UTC)

• {{cite journal|doi=10.3389/fpsyt.2018.00611|pmid=30510526|pmc=6252360|title=Prenatal Progestin Exposure is Associated with Autism Spectrum Disorders|journal=Frontiers in Psychiatry|volume=9|pages=611|year=2018|last1=Li|first1=Ling|last2=Li|first2=Min|last3=Lu|first3=Jianping|last4=Ge|first4=Xiaohu|last5=Xie|first5=Weiguo|last6=Wang|first6=Zichen|last7=Li|first7=Xiaoling|last8=Li|first8=Chao|last9=Wang|first9=Xiaoyan|last10=Han|first10=Yan|last11=Wang|first11=Yifei|last12=Zhong|first12=Liyan|last13=Xiang|first13=Wei|last14=Huang|first14=Xiaodong|last15=Chen|first15=Haijia|last16=Yao|first16=Paul}}
• {{cite journal|doi=10.1186/s13229-017-0159-3|pmid=28824796|title=Prenatal levonorgestrel exposure induces autism-like behavior in offspring through ERβ suppression in the amygdala|journal=Molecular Autism|volume=8|year=2017|last1=Zou|first1=Yuanlin|last2=Lu|first2=Qiaomei|last3=Zheng|first3=Dan|last4=Chu|first4=Zhigang|last5=Liu|first5=Zhaoyu|last6=Chen|first6=Haijia|last7=Ruan|first7=Qiongfang|last8=Ge|first8=Xiaohu|last9=Zhang|first9=Ziyun|last10=Wang|first10=Xiaoyan|last11=Lou|first11=Wenting|last12=Huang|first12=Yongjian|last13=Wang|first13=Yifei|last14=Huang|first14=Xiaodong|last15=Liu|first15=Zhengxiang|last16=Xie|first16=Weiguo|last17=Zhou|first17=Yikai|last18=Yao|first18=Paul}}
• {{cite journal|doi=10.1007/s10803-015-2587-2|pmid=26370672|title=Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California|journal=Journal of Autism and Developmental Disorders|volume=46|issue=2|pages=478–488|year=2016|last1=Windham|first1=Gayle C.|last2=Lyall|first2=Kristen|last3=Anderson|first3=Meredith|last4=Kharrazi|first4=Martin}}
• {{cite journal|doi=10.1038/mp.2014.48|pmid=24888361|title=Elevated fetal steroidogenic activity in autism|journal=Molecular Psychiatry|volume=20|issue=3|pages=369–376|year=2015|last1=Baron-Cohen|first1=S.|last2=Auyeung|first2=B.|last3=Nørgaard-Pedersen|first3=B.|last4=Hougaard|first4=D. M.|last5=Abdallah|first5=M. W.|last6=Melgaard|first6=L.|last7=Cohen|first7=A. S.|last8=Chakrabarti|first8=B.|last9=Ruta|first9=L.|last10=Lombardo|first10=M. V.}}

and many others. — kashmīrī ^TALK 05:16, 27 July 2019 (UTC)

• the article name is "progestin" but most of the article talks about "progestogen". Shouold the article be renamed or possibly split with a small "progestin" article linking here?
• the recently introduced text "A progestin is a synthetic progestogen, as opposed to the natural hormone progesterone" is a bit oddly formulated.

Richiez (talk) 19:17, 14 December 2019 (UTC)

A little bit more nitpicking:

• Overview/Side effects - should probably mention that the side effects are wildly different depending on the particular substance
• Birth control - should probably mention that mostly (exclusively?) progestins are used for this purpose in practice

Richiez (talk) 22:04, 18 December 2019 (UTC)