Talk:Ruthenium diamine complexes
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MEDRS
WP:MEDRS requires all biomedical claims to be sourced to good-quality secondary sources. As far as I can ascertain, none of the references in the Developing ruthenium diamine complexes as anticancer drugs section meet those standards. I've therefore removed the following text, which is sourced to primary studies that don't even seem to have a PubMed index:
- The excellent stability and water-solubility of ruthenium diamine complexes make them a promising research direction in the field of anti-cancer drug developing. Their high selectivity in the binding with DNA aids the design of more effective anticancer complexes.Chen H.; Parkinson, J. A.; Morris, R. E.; Sadler, P. J. J. Am. Chem. Soc. 2003, 125, 173-186. Methylation or substitution on en-NH, which prevent the hydrogen bonding, can lead to the loss of cytotoxic activity of the complex toward cancer cell. The arene and diamine group provide decent scope for modification and optimising in future drug design.Yan, Y. K; Melchart, M.; Habtemariam, a.; Sadler, P. J. Organometallic chemistry, biology and medicine: ruthenium arena anticancer complexes. Chem. Common.[online] 2005, 4764-4776 Futhermone, ability to target specific cancer cells, such as ovarian cancer cells which are resistant to cisplatin makes ruthenium diamine complexes good alternative or addition to cisplatin, and research shows that these two drugs have very limited cross resistance.Antonarakis, E. S.; Emadi, A.; Ruthenium-based chemotherapeutics: are they ready for prime time?. Cancer chemother. Pharmacy, 2010, 66, 1-9.
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Other thoughts would be welcome. --RexxS (talk) 21:21, 16 March 2016 (UTC)