Teg49 small RNA
{{short description|Non-coding RNA}}
{{Infobox rfam
| Name = Teg49 sRNA
| image = RF02696.svg
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| caption = Predicted secondary structure and sequence conservation of Teg49 small RNA
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| Rfam = RF02696
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| Tax_domain = Bacteria
| GO = {{GO|0009405}}
| SO = {{SO|0000370}}
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Teg49 is a non-coding RNA present in the extended promoter region of the staphylococcal accessory regulator sarA. It was identified by RNA-seq and confirmed by Northern blot. It is modulated by sigB (sarA regulator{{cite journal | vauthors = Cheung AL, Chien YT, Bayer AS | title = Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus | journal = Infection and Immunity | volume = 67 | issue = 3 | pages = 1331–1337 | date = March 1999 | doi = 10.1128/IAI.67.3.1331-1337.1999 | pmid = 10024579 | pmc = 96465 }}) and cshA (an ATP-dependant DEAD box RNA helicase{{cite journal | vauthors = Oun S, Redder P, Didier JP, François P, Corvaglia AR, Buttazzoni E, Giraud C, Girard M, Schrenzel J, Linder P | title = The CshA DEAD-box RNA helicase is important for quorum sensing control in Staphylococcus aureus | journal = RNA Biology | volume = 10 | issue = 1 | pages = 157–165 | date = January 2013 | pmid = 23229022 | pmc = 3590232 | doi = 10.4161/rna.22899 | url = https://archive-ouverte.unige.ch/unige:28414/ATTACHMENT01 }}) and it most likely contributes to virulence of S. aureus by modulating SarA expression.{{cite journal | vauthors = Kim S, Reyes D, Beaume M, Francois P, Cheung A | title = Contribution of teg49 small RNA in the 5′ upstream transcriptional region of sarA to virulence in Staphylococcus aureus | journal = Infection and Immunity | volume = 82 | issue = 10 | pages = 4369–4379 | date = October 2014 | pmid = 25092913 | pmc = 4187880 | doi = 10.1128/IAI.02002-14 }}