Thrombospondin 3
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Thrombospondin-3 (TSP3) is a protein that in humans is encoded by the THBS3 gene.{{cite journal | vauthors = Vos HL, Devarayalu S, de Vries Y, Bornstein P | title = Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family | journal = The Journal of Biological Chemistry | volume = 267 | issue = 17 | pages = 12192–12196 | date = June 1992 | pmid = 1601886 | doi = 10.1016/S0021-9258(19)49823-2 | doi-access = free }}{{cite web | title = Entrez Gene: THBS3 thrombospondin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7059}}
The protein encoded by this gene belongs to the thrombospondin family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. TSP3 has been found to be involved in the regulation of skeletal maturation.{{cite journal | vauthors = Hankenson KD, Hormuzdi SG, Meganck JA, Bornstein P | title = Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head | journal = Molecular and Cellular Biology | volume = 25 | issue = 13 | pages = 5599–5606 | date = July 2005 | pmid = 15964815 | pmc = 1156967 | doi = 10.1128/MCB.25.13.5599-5606.2005 }} This protein forms a pentameric molecule linked by a single disulfide bond. This gene shares a common promoter with metaxin 1. Identified as the gene on chromosome 1 responsible for mediating an associated with genetic susceptibility to SARS-CoV-2 infection.{{cite journal | vauthors = Niemi ME, Karjalainen J, Liao RG, Neale BM, Daly M, Ganna A, Pathak GA, Andrews SJ, Kanai M, Veerapen K, Fernandez-Cadenas I, Schulte EC, Striano P, Marttila M, Minica C, Marouli E, Karim MA, Wendt FR, Savage J, Sloofman L, Butler-Laporte G, Kim HN, Kanoni S, Okada Y, Byun J, Han Y, Uddin MJ, Smith GD, Willer CJ, Buxbaum JD | title = Mapping the human genetic architecture of COVID-19 | journal = Nature | volume = 600 | issue = 7889 | pages = 472–477 | date = December 2021 | pmid = 34237774 | pmc = 8674144 | doi = 10.1038/s41586-021-03767-x | bibcode = 2021Natur.600..472C | s2cid = 235776838 }}
References
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Further reading
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- {{cite journal | vauthors = O'Rourke KM, Laherty CD, Dixit VM | title = Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers | journal = The Journal of Biological Chemistry | volume = 267 | issue = 35 | pages = 24921–24924 | date = December 1992 | pmid = 1459996 | doi = 10.1016/S0021-9258(19)73983-0 | doi-access = free }}
- {{cite journal | vauthors = Adolph KW, Long GL, Winfield S, Ginns EI, Bornstein P | title = Structure and organization of the human thrombospondin 3 gene (THBS3) | journal = Genomics | volume = 27 | issue = 2 | pages = 329–336 | date = May 1995 | pmid = 7558000 | doi = 10.1006/geno.1995.1050 }}
- {{cite journal | vauthors = Qabar A, Derick L, Lawler J, Dixit V | title = Thrombospondin 3 is a pentameric molecule held together by interchain disulfide linkage involving two cysteine residues | journal = The Journal of Biological Chemistry | volume = 270 | issue = 21 | pages = 12725–12729 | date = May 1995 | pmid = 7759526 | doi = 10.1074/jbc.270.21.12725 | doi-access = free }}
- {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–174 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
- {{cite journal | vauthors = Qabar AN, Lin Z, Wolf FW, O'Shea KS, Lawler J, Dixit VM | title = Thrombospondin 3 is a developmentally regulated heparin binding protein | journal = The Journal of Biological Chemistry | volume = 269 | issue = 2 | pages = 1262–1269 | date = January 1994 | pmid = 8288588 | doi = 10.1016/S0021-9258(17)42252-6 | doi-access = free }}
- {{cite journal | vauthors = Bornstein P, Devarayalu S, Edelhoff S, Disteche CM | title = Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene | journal = Genomics | volume = 15 | issue = 3 | pages = 607–613 | date = March 1993 | pmid = 8468055 | doi = 10.1006/geno.1993.1114 }}
- {{cite journal | vauthors = Winfield SL, Tayebi N, Martin BM, Ginns EI, Sidransky E | title = Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease | journal = Genome Research | volume = 7 | issue = 10 | pages = 1020–1026 | date = October 1997 | pmid = 9331372 | pmc = 310674 | doi = 10.1101/gr.7.10.1020 }}
- {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–156 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
- {{cite journal | vauthors = Adolph KW | title = Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues | journal = Biochemical and Biophysical Research Communications | volume = 258 | issue = 3 | pages = 792–796 | date = May 1999 | pmid = 10329465 | doi = 10.1006/bbrc.1999.0710 }}
- {{cite journal | vauthors = Adolph KW, Bornstein P | title = The human thrombospondin 3 gene: analysis of transcription initiation and an alternatively spliced transcript | journal = Molecular Cell Biology Research Communications | volume = 2 | issue = 1 | pages = 47–52 | date = July 1999 | pmid = 10527891 | doi = 10.1006/mcbr.1999.0148 }}
- {{cite journal | vauthors = Carron JA, Hiscott P, Hagan S, Sheridan CM, Magee R, Gallagher JA | title = Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4 | journal = The International Journal of Biochemistry & Cell Biology | volume = 32 | issue = 11–12 | pages = 1137–1142 | year = 2001 | pmid = 11137453 | doi = 10.1016/S1357-2725(00)00065-0 }}
- {{cite journal | vauthors = Armstrong DJ, Hiscott P, Batterbury M, Kaye S | title = Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype | journal = The International Journal of Biochemistry & Cell Biology | volume = 34 | issue = 6 | pages = 588–593 | date = June 2002 | pmid = 11943589 | doi = 10.1016/S1357-2725(01)00157-1 }}
- {{cite journal | vauthors = Dalla-Torre CA, Yoshimoto M, Lee CH, Joshua AM, de Toledo SR, Petrilli AS, Andrade JA, Chilton-MacNeill S, Zielenska M, Squire JA | title = Effects of THBS3, SPARC and SPP1 expression on biological behavior and survival in patients with osteosarcoma | journal = BMC Cancer | volume = 6 | pages = 237 | date = October 2006 | pmid = 17022822 | pmc = 1609181 | doi = 10.1186/1471-2407-6-237 | doi-access = free }}
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