Timeline of cancer treatment development

Cancer was traditionally treated with surgery, heat, or herbal (chemical) therapies.

• 2600 BC {{spaced ndash}} Egyptian physician Imhotep diagnosed several types of tumour and therapies for them. According to the Ebers medical papyrus, hard tumours were treated by placing a poultice near the tumour, followed by local incision.{{cite journal | vauthors = Kucerova P, Cervinkova M | title = Spontaneous regression of tumour and the role of microbial infection--possibilities for cancer treatment | journal = Anti-Cancer Drugs | volume = 27 | issue = 4 | pages = 269–77 | date = April 2016 | pmid = 26813865 | pmc = 4777220 | doi = 10.1097/CAD.0000000000000337}}
• BC {{spaced ndash}} Ancient Greeks, Romans, and Egyptians used heat to treat masses. Healers in ancient India used regional and whole-body hyperthermia as treatments.{{cite book |author=Gian F. Baronzio |title=Hyperthermia In Cancer Treatment: A Primer |series=Medical Intelligence Unit |publisher=Springer |location=Berlin |year=2006 |chapter=Introduction |isbn=978-0-387-33440-0}}{{page needed|date=April 2014}}
• 2 AD {{spaced ndash}} Ancient Greeks describe surgical treatment of cancer.{{cite web | title = The History of Cancer.| url=http://www.cancer.org/cancer/cancerbasics/thehistoryofcancer/the-history-of-cancer-what-is-cancer}}{{cite web | title = History of cancer treatment.| url=http://raconteur.net/healthcare/history-of-cancer-treatment| date=2015-06-04}}

• 1820s {{spaced ndash}} British Dr. James Arnott, "the father of modern cryosurgery", starts to use cryotherapy to freeze tumours in the treatment of breast and uterine cancers{{cite book | year = 2008 |title = History of Cryosurgery. | url=http://www.fudahospital.com/alb_asp_new/show_crosurgery_book.asp?page=crosurgery_1_1}}
• 1880s {{spaced ndash}} American Dr. William Stewart Halsted develops radical mastectomy for breast cancer
• 1890s {{spaced ndash}} German Dr. Westermark used localized hyperthermia to produce tumour regression in patients
• 1891 {{spaced ndash}} American Dr. William B. Coley, "the father of immunotherapy", starts to treat cancer patients by injecting them with streptococci, containing immunostimulatory CpG motifs{{cite journal |pmid=7700380 |year=1995 |last1=Krieg |first1=AM |last2=Yi |last3=Matson |last4=Waldschmidt |last5=Bishop |last6=Teasdale |last7=Koretzky |last8=Klinman |title=CpG motifs in bacterial DNA trigger direct B-cell activation |volume=374 |issue=6522 |pages=546–9 |doi=10.1038/374546a0 |journal=Nature |first2=AK |first3=S |first4=TJ |first5=GA |first6=R |first7=GA |first8=DM|bibcode=1995Natur.374..546K |s2cid=4261304 }}{{cite journal |title = The Toxins of William B. Coley and the Treatment of Cancer. | pmc=1888599 | pmid=16789469 | volume=26 | year=2006 | journal=Iowa Orthop J | pages=154–8 | last1 = McCarthy | first1 = EF}}
• 1896 {{spaced ndash}} French Dr. Victor Despeignes, "the father of radiation therapy", starts to use X-rays to treat cancer{{cite journal | title = The physician who first applied radiotherapy, Victor Despeignes, on 1896.| journal=Hellenic Journal of Nuclear Medicine| volume=17| issue=1| pages=45–6| url=https://www.researchgate.net/publication/260376291| doi=| pmid=24563880| year=2014| last1=Sgantzos| first1=M.| last2=Tsoucalas| first2=G.| last3=Laios| first3=K.| last4=Androutsos| first4=G.}}
• 1896 {{spaced ndash}} American Dr. Emil Grubbe starts to treat breast cancer patients with X-rays
• 1896 Sir George Thomas Beatson invented hormonal treatment of breast cancer by bilateral ovary removal in women with inoperable breast cancer.

• 1900 {{spaced ndash}} Swedish Dr. Stenbeck cures a skin cancer with small doses of radiation
• 1920s {{spaced ndash}} Dr. William B. Coley's immunotherapy treatment, regressed tumors in hundreds of cases, the success of Coley's Toxins attracted heavy resistance from his rival and supervisor, Dr. James Ewing, who was an ardent supporter of radiation therapy for cancer. This rivalry and opposition to Dr. Coley leads to the disuse of immunotherapy for cancer, in favor of Dr. Ewing's preferred radiation therapy{{cite journal|title=The Toxins of William B. Coley and the Treatment of Bone and Soft-Tissue Sarcomas| pmc=1888599 | pmid=16789469 | volume=26| year=2006| journal=Iowa Orthop J| pages=154–8 | last1 = McCarthy | first1 = EF}}
• 1939 {{spaced ndash}} American Dr. Charles Huggins uses synthetic hormone therapy to treat prostate cancer
• 1942 {{spaced ndash}} First chemotherapy drug mustine used to treat cancer{{cite journal | title = First Use of Intravenous Chemotherapy Cancer Treatment: Rectifying the Record.| journal=Journal of the American College of Surgeons| volume=212| issue=3| pages=413–417| url=http://www.journalacs.org/article/S1072-7515%2810%2901211-1/abstract| doi=10.1016/j.jamcollsurg.2010.10.018| pmid=21247779| year=2011| last1=Fenn| first1=John E.| last2=Udelsman| first2=Robert}}
• 1947 {{spaced ndash}} American Dr. Sidney Farber induces brief remission in a patient with leukaemia with the antifolate drug aminopterin (methotrexate)
• 1949 {{spaced ndash}} US FDA approves mechlorethamine, a nitrogen mustard compound, for treatment of cancer{{cite web|title=Milestones in Cancer Research and Discovery|url=https://www.cancer.gov/research/progress/250-years-milestones|date=2015-01-21}}
• 1949 {{spaced ndash}} Oncolytic viruses began human clinical trials{{cite web|title=Clinical virotherapy: four historically significant clinical trials|url=http://www.nature.com/mt/journal/v15/n4/fig_tab/6300108t1.html#figure-title}}{{cite journal|last=Huebner|first=RJ|author2=Rowe, WP |author3=Schatten, WE |author4=Smith, RR |author5= Thomas, LB |title=Studies on the use of viruses in the treatment of carcinoma of the cervix|journal=Cancer|date=Nov–Dec 1956|volume=9|issue=6|pages=1211–8|pmid=13383455|doi=10.1002/1097-0142(195611/12)9:6<1211::AID-CNCR2820090624>3.0.CO;2-7|doi-access=free}}
• 1951 {{spaced ndash}} Dr. Jane C. Wright demonstrated the use of the antifolate, methotrexate in solid tumors, showing remission in breast cancer
• 1950s {{spaced ndash}} Anti-cancer anthracyclines isolated from the Streptomyces peucetius bacteria. Anthracycline-based derivatives include: daunorubicin, doxorubicin, amrubicin, idarubicin{{Cite journal | last1 = Fujiwara | first1 = A.| last2 = Hoshino | first2 = T. | last3 = Westley | first3 = J. W. | doi = 10.3109/07388558509150782 | title = Anthracycline Antibiotics | journal = Critical Reviews in Biotechnology | volume = 3 | issue = 2 | pages = 133–157 | year = 1985 }}
• 1953 {{spaced ndash}} US FDA approves mercaptopurine (6 MP), an immunosuppressive agent{{cite book |title =A Master of Science History: Essays in Honor of Charles Coulston Gillispie.| url=https://books.google.com/books?id=jZQM_bzvj3cC&pg=PA285| isbn=9789400726260| last1=Buchwald| first1=Jed Z.| date=2012-01-05| publisher=Springer }}
• 1956 {{spaced ndash}} Metastatic choriocarcinoma cancer is cured with the antifolate, methotrexate
• 1956 {{spaced ndash}} First bone marrow transplantation performed by E. Donnall Thomas in order to treat leukemia in one of two identical twins, the healthy twin being the donor{{cite news |title=1956: the first successful bone marrow transplantation |url=https://home.cancerresearch/1956-the-first-successful-bone-marrow-transplantation/ |website=home.cancerresearch |date=7 December 2014 |publisher=Australian Cancer Research Foundation |access-date=31 May 2021 |language=English}}
• 1957 {{spaced ndash}} Introduction of fluorouracil to treat colorectal, breast, stomach, and pancreatic cancers
• 1957 {{spaced ndash}} Introduction of interferon to treat kidney, skin, and bladder cancer
• 1958 {{spaced ndash}} Combination therapy consisting of 6-mercaptopurine and methotrexate results in a cure of leukaemia in a trial run in US hospitals
• 1958 {{spaced ndash}} US FDA approves cyclophosphamide for chemotherapy of cancer{{cite journal | vauthors = Emadi A, Jones RJ, Brodsky RA | title = Cyclophosphamide and cancer: golden anniversary | journal = Nat Rev Clin Oncol | volume = 6 | issue = 11 | pages = 638–47 | year = 2009 | pmid = 19786984 | doi = 10.1038/nrclinonc.2009.146 | s2cid = 18219134 }}
• 1960s {{spaced ndash}} Introduction of laser therapy in treatment of cancer{{cite journal | year = 1966 |title =A review: Applications of the laser beam in cancer biology. | author = Goldman| doi=10.1002/ijc.2910010402 | volume=1 |issue =4 | journal=International Journal of Cancer | pages=309–318|s2cid =72256690 }}
• 1960 {{spaced ndash}} Invention of tamoxifen breast cancer anti-estrogen (SERM) hormonal therapy drug
• 1961 {{spaced ndash}} Vincristine, anti-cancer alkaloid, isolated from the Madagascar periwinkle plant{{cite book|last1=Ravina|first1=Enrique|title=The evolution of drug discovery : from traditional medicines to modern drugs|date=2011|publisher=Wiley-VCH|location=Weinheim|isbn=9783527326693|pages=157–159|edition=1. Aufl.|url=https://books.google.com/books?id=iDNy0XxGqT8C&pg=PA157}}
• 1962 {{spaced ndash}} US FDA disapproves Dr. Coley's immunotherapy, making it illegal; radiation therapy remained the dominant treatment for cancer
• 1963 {{spaced ndash}} US FDA approves vincristine (Oncovin) for chemotherapy of cancer
• 1964 {{spaced ndash}} VAMP regimen combination therapy, consisting of: vincristine, amethopterin, 6-mercaptopurine, and prednisone, induces long-term remissions in juvenile acute lymphoblastic leukemia{{cite journal | title = A History of Cancer Chemotherapy | journal=Cancer Research| volume=68| issue=21| pages=8643–8653| url=http://cancerres.aacrjournals.org/content/68/21/8643| doi=10.1158/0008-5472.CAN-07-6611| pmid=18974103| year=2008| last1=Devita| first1=Vincent T.| last2=Chu| first2=Edward| doi-access=free}}
• 1965 {{spaced ndash}} MOPP regimen combination therapy cures advanced Hodgkin's lymphoma, with the combination of: nitrogen mustard, vincristine, procarbazine, and prednisone
• 1965 {{spaced ndash}} MOMP regimen combination therapy, consisting of: methotrexate, vincristine, 6-MP, and prednisone, induces long-term remissions in juvenile acute lymphoblastic leukemia
• 1965 {{spaced ndash}} Latvian scientist Aina Muceniece identifies echovirus as a potential agent for oncolytic virotherapy, resulting in the development of RIGVIRMuceniece A.J., Bumbieris J.V. 1982. Transplantation antigens and their changes in carcinogenesis and viral infection. In: Virusnyi onkoliz i iskusstvennaya geterogenizatsiya opukholei (Viral Oncolysis and Artificial Heterogenization of Tumors). Riga, pp. 217–234.
• 1966 {{spaced ndash}} Taxol, anti-cancer compound, isolated from the yew plant
• 1967 {{spaced ndash}} Camptothecin, anti-cancer compound, isolated from the Camptotheca acuminata, the Chinese Happy Tree, which was used as a cancer treatment in traditional Chinese medicine.the stem bark of Mappia foetida, a tree native to India, has proved to be another source significant for the isolation of camptothecin. TR Govindachari and N. Viswnathan, Phytochemistry 11(12), 3529-31 (1972). {{Cite journal|vauthors=Efferth T, Fu YJ, Zu YG, Schwarz G, Konkimalla VS, Wink M | title = Molecular target-guided tumor therapy with natural products derived from traditional Chinese medicine. | year = 2007 | journal = Current Medicinal Chemistry | volume = 14 | pages = 2024–32 | doi = 10.2174/092986707781368441| pmid = 17691944 | issue = 19 }} It is the source of chemotherapy drugs: topotecan and irinotecan.
• 1968 {{spaced ndash}} Japanese Dr. Tanaka pioneers the treatment of metastatic breast cancer with cryoablation, resulting in prolonged survival{{cite journal | year = 1982 |title = Immunological aspects of cryosurgery in general surgery.| journal = Cryobiology | author = Tanaka| pmid=7105777 | doi=10.1016/0011-2240(82)90151-1 | volume=19 |issue = 3| pages=247–62}}{{cite journal | year = 1998 |title = The Use of Cryosurgery for Breast Cancer | url=http://archsurg.jamanetwork.com/article.aspx?articleid=211464 | journal = Arch Surg | language = en|author = Richard J. Ablin, PhD | doi = 10.1001/archsurg.133.1.106 |pmid = 9438770 | volume=133 |issue = 1 | page=106}}
• 1972 {{spaced ndash}} UK and other European countries approve tamoxifen for breast cancer
• 1972 {{spaced ndash}} American Dr. Lawrence Einhorn cures metastatic testicular cancer with cisplatin{{cite journal |title = Timeline: Milestones in Cancer Treatment | date=3 October 2008| url=http://www.curetoday.com/publications/cure/2008/special-issue2008/timeline-milestones-in-cancer-treatment| last1=Meyer| first1=Lacey| journal=Cure| series=Special Issue 2008| volume=7| issue=4}}
• 1975 {{spaced ndash}} Invention of monoclonal antibodies
• 1975 {{spaced ndash}} American Dr. Einhorn shows combination therapy consisting of cisplatinum, vinblastine, and bleomycin can cure 70% of advanced testicular cancer cases
• 1975 {{spaced ndash}} C-MOPP regimen combination therapy, consisting of: methotrexate, vincristine, cyclophosphamide, and prednisone, cured advanced diffuse large B-cell lymphoma
• 1977 {{spaced ndash}} US FDA approves tamoxifen for metastatic breast cancer only, not widely popular as chemotherapy remains first line of treatment{{cite book | title = Tamoxifen: Pioneering Medicine in Breast Cancer.| url=https://books.google.com/books?id=p-W5BAAAQBAJ&pg=PA186| isbn=9783034806640| last1=Maximov| first1=Philipp Y.| last2=McDaniel| first2=Russell E.| last3=Craig Jordan| first3=V.| date=2013-07-23| publisher=Springer }}Tamoxifen was born into a world of indifference in the '60s, when the focus of the research was on contraception. It grew up in the 70s, in a world where chemotherapy was king and hormonal therapies were perceived as non-starters in the quest to cure cancer.{{cite journal | title = Tamoxifen: a personal retrospective.| journal=The Lancet Oncology| volume=1| issue=1| pages=43–49| url=http://www.thelancetnorway.com/pdfs/journals/lanonc/PIIS1470-2045(00)00009-7.pdf| doi=10.1016/S1470-2045(00)00009-7| pmid=11905688| year=2000| last1=Jordan| first1=V Craig}}
• 1981 {{spaced ndash}} American Dr. Bernard Fisher proves lumpectomy is as effective as mastectomy for breast cancer
• 1989 {{spaced ndash}} US FDA approves Carboplatin, a derivative of cisplatin, for chemotherapy
• 1990 {{spaced ndash}} US FDA approves tamoxifen for major additional use to help prevent the recurrence of cancer in "node-negative" patients{{cite web |title = Center for Devices and Radiological Health U.S. Food and Drug Administration. | website=Food and Drug Administration| url=https://www.fda.gov/ohrms/dockets/ac/03/briefing/3973b1_summary.htm}}
• 1990 {{spaced ndash}} China begins treating various cancers with photodynamic therapy{{Cite journal| volume = 3| issue = 1| pages = 3–10| last = Huang| first = Z| title = Photodynamic therapy in China: Over 25 years of unique clinical experience: Part One—History and domestic photosensitizers| journal = Photodiagnosis and Photodynamic Therapy| year = 2006| doi = 10.1016/S1572-1000(06)00009-3| pmid = 25049020}}

{{Cite journal| volume = 4| issue = 1| pages = 13–25| last = Xu| first = DY| title = Research and development of photodynamic therapy photosensitizers in China | journal = Photodiagnosis and Photodynamic Therapy| year = 2007| doi = 10.1016/j.pdpdt.2006.09.003| pmid = 25047186}}

• 1991 {{spaced ndash}} First gene therapy treatment of cancer (melanoma)
• 1992 {{spaced ndash}} Invention of tyrosine-kinase inhibitor Imatinib{{cite web |title = The Story of Gleevec |url = http://www.innovation.org/index.cfm/StoriesofInnovation/InnovatorStories/The_Story_of_Gleevec |url-status = dead |archive-url = https://web.archive.org/web/20131021011042/http://www.innovation.org/index.cfm/StoriesofInnovation/InnovatorStories/The_Story_of_Gleevec |archive-date = 2013-10-21 }}
• 1992 {{spaced ndash}} Invention of Etacstil breast cancer anti-estrogen (SERM/SERD) hormonal therapy drug that overcomes hormone-therapy resistance{{cite journal |title = a non-steroidal estrogen with functional selectivity for bone over uterus in rats. | pmid=8201587 | volume=37 | issue=11 | journal=J Med Chem | pages=1550–2 | last1 = Willson | first1 = TM | last2 = Henke | first2 = BR | last3 = Momtahen | first3 = TM | last4 = Charifson | first4 = PS | last5 = Batchelor | first5 = KW | last6 = Lubahn | first6 = DB | last7 = Moore | first7 = LB | last8 = Oliver | first8 = BB | last9 = Sauls | first9 = HR | last10 = Triantafillou | first10 = JA | doi=10.1021/jm00037a002| year=1994 }}{{cite web | title = Tamoxifen-like drug suggests new ways to selectively block estrogen.| url=http://www.uchospitals.edu/news/2005/20050512-gw5638.html}}
• 1996 {{spaced ndash}} US FDA approves antiestrogen, aromatase inhibitor Anastrozole for advanced breast cancer
• 1996 {{spaced ndash}} Russia begins treating various cancers with photodynamic therapy{{Cite web| title = Centre of laser medicine — Historical Aspects of Photodynamic Therapy Development| access-date = 2011-08-05| url = http://www.magicray.ru/ENG/lecture/L2/2.html}}

• 1997 {{spaced ndash}} First monoclonal antibody, Rituximab, is licensed
• 1997 {{spaced ndash}} Chinese doctors start treating uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumours, and renal cancer with ultrasound imaging-guided high-intensity focused ultrasoundIn 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors.{{cite journal | year = 2010 |title = High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience. | doi=10.1007/s11684-010-0092-8 |pmid = 21191835 | volume=4 |issue = 3 | journal=Frontiers of Medicine in China | pages=294–302|last1 = Zhang |first1 = Lian |last2 = Wang |first2 = Zhi-Biao |s2cid = 21219521 }}
• 1998 {{spaced ndash}} Chinese doctors start treating breast, kidney, lung, liver, prostate and bone cancer with imaging-guided cryoablation{{cite book | year = 1997 |title = History of Cryosurgery. | url=http://www.fudahospital.com/alb_asp_new/show_crosurgery_book.asp?page=crosurgery_1_1}}{{cite web |title = FAQ | url=http://keepingthem.com/faq/}}
• 1998 {{spaced ndash}} US FDA approves herceptin, a monoclonal antibody for HER2 metastatic breast cancer
• 1998 {{spaced ndash}} US FDA approves cryoablation for the treatment of prostate cancer
• 1998 {{spaced ndash}} US FDA approves Camptothecin-analogue irinotecan for chemotherapy of cancer{{cite web |title =FDA Review Letter | url= http://www.accessdata.fda.gov/drugsatfda_docs/appletter/1998/20571s8ltr.pdf}}
• 1998 {{spaced ndash}} US FDA approves tamoxifen to reduce breast cancer risk in high-risk patients
• 1998 {{spaced ndash}} US FDA approves monoclonal antibody, Trastuzumab for advanced HER-2 breast cancer
• 1998 {{spaced ndash}} Imaging-guided High-intensity focused ultrasound is approved for use in Europe for treatment of cancer{{cite web |title =History of Ablatherm HIFU | url= http://www.hifu.ca/history-ablatherm-hifu.htm}}

• 2001 {{spaced ndash}} UK NICE approves taxol for chemotherapy of breast, ovarian, and non-small cell lung cancers{{cite web|url=http://www.bnf.org/bnf/bnf/current/21850.htm|title=British National Formulary}}
• 2002 {{spaced ndash}} US FDA approves imatinib
• 2002 {{spaced ndash}} The State Food and Drug Administration of China approves Gendicine, gene therapy for cancer{{cite journal|title=China approves first gene therapy|journal=Nature Biotechnology|year=2004|volume=22|issue=1|pages=3–4|pmid=14704685|doi=10.1038/nbt0104-3 | last1 = Pearson | first1 = S | last2 = Jia | first2 = H | last3 = Kandachi | first3 = K | pmc=7097065}}
• 2002 {{spaced ndash}} Corporate takeover of Dupont by BMS resulted in abandoning Etacstil breast cancer anti-estrogen (SERM/SERD) hormonal therapy drug that overcomes hormone-therapy resistance{{cite web |title =how breast cancer drugs are developed | date=17 June 2013| url=http://www.medicalnewstoday.com/articles/262039.php}}
• 2003 {{spaced ndash}} American Dr. Peter Littrup starts to treat early and metastatic breast cancer with cryoablationAccording to Littrup et al., who performed cryoablation of breast tumors in clinical stages I-IV with a multi-probe freeze approach, isotherms within cryozones can be accurately controlled and such cryoablation enables the destruction of much bigger lesions, up to 7 cm in diameter (15){{cite journal | year = 2014 |title = Cryosurgery in the treatment of women with breast cancer. | pmc=4115762 | pmid=25083502 | doi=10.3978/j.issn.2227-684X.2014.03.04 | volume=3 |issue = 2 | journal=Gland Surg | pages=88–93 | last1 = Tarkowski | first1 = R | last2 = Rzaca | first2 = M}}
• 2004 {{spaced ndash}} bevacizumab, the first approved drug to inhibit blood vessel formation by tumours, is licensed
• 2005 {{spaced ndash}} US FDA approves taxol for chemotherapy of breast, pancreatic, and non-small cell lung cancers{{Cite web|url = http://www.cancer.org/treatment/treatmentsideeffects//guidetocancerdrugs/paclitaxel-protein-bound-suspension|title = Paclitaxel, Protein-Bound Suspension|date = January 6, 2015|access-date = January 24, 2015|website = Paclitaxel, Protein-Bound Suspension|publisher = Cancer.Org}}
• 2006 {{spaced ndash}} US FDA approves herceptin
• 2007 {{spaced ndash}} US FDA approves sorafenib
• 2007 {{spaced ndash}} US FDA approves camptothecin-analogue topotecan for chemotherapy of cancer
• 2010 {{spaced ndash}} US FDA approves immunotherapy, sipuleucel-T dendritic cell vaccine for advanced prostate cancer
• 2010 {{spaced ndash}} China advances cryoimmunotherapy to treat breast, kidney, lung, liver, prostate and bone cancer{{cite web | year = 2013 |title = International Cryosurgery Center | url=http://www.fudahospital.com/id_asp_new/show_info.asp?typename=News&typename2=events&article_showid=1489}}{{cite journal |title = Combination treatment with comprehensive cryoablation and immunotherapy in metastatic hepatocellular cancer | pmc=3683687 | pmid=23801841 | doi=10.3748/wjg.v19.i22.3473 | volume=19 | issue=22 | year=2013 | journal=World J. Gastroenterol. | pages=3473–80 | last1 = Niu | first1 = LZ | last2 = Li | first2 = JL | last3 = Zeng | first3 = JY | last4 = Mu | first4 = F | last5 = Liao | first5 = MT | last6 = Yao | first6 = F | last7 = Li | first7 = L | last8 = Liu | first8 = CY | last9 = Chen | first9 = JB | last10 = Zuo | first10 = JS | last11 = Xu | first11 = KC | doi-access=free }}{{cite web |title = thechinastory| url=http://keepingthem.com/category/thechinastory/}}
• 2011 {{spaced ndash}} US FDA approves monoclonal antibody, Ipilimumab for advanced melanoma
• 2011 {{spaced ndash}} Cuba develops and releases CimaVax-EGF, the first therapeutic cancer vaccine for lung cancer{{cite news|url=http://www.popsci.com/science/article/2011-09/cuba-releases-worlds-first-lung-cancer-vaccine|title=Cuba Announces Release of the World's First Lung Cancer Vaccine|publisher=PopSci|date=2011-08-09|access-date=2011-12-11}}
• 2012 {{spaced ndash}} Cuba develops and releases monoclonal antibody, Racotumomab, the therapeutic cancer vaccine for lung cancerVázquez, A.M, Hernández, A.M., Macías, A., et al. (2012). Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides – preclinical and clinical data. Front Oncol. 2012;2:150.
• 2015 {{spaced ndash}} US FDA approves anti-CDK4/6, Palbociclib for advanced breast cancer
• 2015 {{spaced ndash}} US FDA approves imaging-guided high-intensity focused ultrasound for prostate cancer{{cite press release |title = FDA approves device used to treat prostate cancer | url=http://www.prnewswire.com/news-releases/fda-approves-device-used-to-treat-prostate-cancer-300158985.html }}

• Treatment of cancer
• History of cancer chemotherapy

{{reflist}}

• [https://books.google.com/books?id=kfYeQSgWSwEC The Rise And Fall Of Modern Medicine]
• [https://books.google.com/books?id=iDNy0XxGqT8C The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs]
• [https://books.google.com/books?id=mtjgBwAAQBAJ Chemotherapy]
• [https://www.cancer.gov/research/progress/discovery/methotrexate Treatment of Solid Tumor Cancers with the Chemotherapy Drug Methotrexate]

Category:Therapy

Category:Cancer

Treatment Development