Tinkisso River

File:USGS geologic map Guinea.png of Guinea showing the course of the Tinkisso]]

The Tinkisso River is a river in Guinea in west Africa. The river is sourced near Dalaba in the Fouta Djallon mountain range, north of Mamou and snakes approximately north-east and then east across the plains of Guinea, until it runs into the River Niger at Siguiri. The river is approximately {{convert|250|mi|km|order=flip|abbr=off}} in length.

The river and the surrounding plains were designated a Ramsar site by the Niger Basin Authority and the Guinean government in 2002. The river and its tributaries are the home to species of manatee.