Tinyatoxin

{{chembox

|Watchedfields = changed

|verifiedrevid = 421304832

|Name = Tinyatoxin

|ImageFile = Tinyatoxin.svg

|ImageClass = skin-invert-image

|ImageSize = 200px

|PIN = [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-Benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,3b,6,6a,7,9a,11,11a-octahydro-2H,10H-2,9b-epoxyazuleno[5,4-e][1,3]benzodioxol-5-yl]methyl (4-hydroxyphenyl)acetate

|Section1 = {{Chembox Identifiers

|CASNo_Ref = {{cascite|correct|??}}

|CASNo = 58821-95-7

|UNII_Ref = {{fdacite|correct|FDA}}

|UNII = WN080Z1OL0

|PubChem = 442098

|ChemSpiderID = 32701427

|ChEBI = 9603

|SMILES = C[C@@H]1C[C@]2([C@H]3[C@H]4[C@]1([C@@H]5C=C(C(=O)[C@]5(CC(=C4)COC(=O)Cc6ccc(cc6)O)O)C)O[C@](O3)(O2)Cc7ccccc7)C(=C)C

|StdInChI = 1S/C36H38O8/c1-21(2)34-17-23(4)36-28(32(34)42-35(43-34,44-36)19-25-8-6-5-7-9-25)15-26(18-33(40)29(36)14-22(3)31(33)39)20-41-30(38)16-24-10-12-27(37)13-11-24/h5-15,23,28-29,32,37,40H,1,16-20H2,2-4H3/t23-,28+,29-,32-,33-,34-,35-,36-/m1/s1

|StdInChIKey = WWZMXEIBZCEIFB-ACAXUWNGSA-N

|MeSHName = tinyatoxin}}

|Section2 = {{Chembox Properties

|C=36

|H=38

|O=8

}}

}}

{{Infobox pepper

|heat = Above peak

|scoville = 5,300,000,000

}}

Tinyatoxin (TTX or TTN) is an analog of the neurotoxin resiniferatoxin. It occurs naturally in Euphorbia poissonii.[http://www.botanical-dermatology-database.info/BotDermFolder/EUPH-9.html#Euphorbia%20poissonii Euphorbia poissonii] in BoDD – Botanical Dermatology Database

It is a neurotoxin that acts via full agonism of the vanilloid receptors of sensory nerves.{{cite journal |author1=Szallasi, A. |author2=Blumberg, P.M. |name-list-style=amp | title = Characterization of vanilloid receptors in the dorsal horn of pig spinal cord | journal = Brain Res | volume = 547 | pages = 335–338 | year = 1991 | doi = 10.1016/0006-8993(91)90982-2 | pmid = 1884211 | issue = 2|s2cid=25052101 }} Tinyatoxin has a potential for pharmaceutical uses similar to uses of capsaicin. Tinyatoxin is about one third as strong as resiniferatoxin but is still an ultrapotent analogue of capsaicin, with a heat intensity estimate of 300 to 350 times that of capsaicin.{{citation needed|date=November 2018}}