Tioconazole

{{Short description|Chemical compound}}

{{Drugbox

| Verifiedfields = changed

| verifiedrevid = 415485693

| IUPAC_name = (RS)-1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole

| image = Tioconazole.svg

| chirality = Racemic mixture

| tradename = Vagistat-1, 1-Day

| Drugs.com = {{drugs.com|monograph|tioconazole}}

| pregnancy_category =

| legal_US= OTC

| routes_of_administration = Topical

| bioavailability =

| protein_bound =

| metabolism =

| elimination_half-life =

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 65899-73-2

| ATC_prefix = D01

| ATC_suffix = AC07

| ATC_supplemental = {{ATC|G01|AF08}}

| PubChem = 5482

| DrugBank_Ref = {{drugbankcite|changed|drugbank}}

| DrugBank = DB01007

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = 5282

| UNII_Ref = {{fdacite|changed|FDA}}

| UNII = S57Y5X1117

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D00890

| ChEBI_Ref = {{ebicite|changed|EBI}}

| ChEBI = 9604

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 1200438

| C=16 | H=13 | Cl=3 | N=2 | O=1 | S=1

| synonyms = Thioconazole

}}

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast. It is marketed under the brand names Trosyd and Gyno-Trosyd (Pfizer, later Johnson & Johnson and now Kenvue). Tioconazole ointments serve to treat women's vaginal yeast infections.[http://www.mayoclinic.com/health/drug-information/DR601345 Tioconazole], Mayo Clinic They are available in one day doses, as opposed to the 7-day treatments commonly used in the past.

Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus".

It was patented in 1975 and approved for medical use in 1982.{{cite book | vauthors = Fischer J, Ganellin CR |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=503 |url=https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA503 |language=en}}

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