Tissue-selective estrogen complex

A tissue-selective estrogen complex (TSEC) is a combination of an estrogen, such as estradiol or conjugated estrogens, and a selective estrogen receptor modulator (SERM), such as tamoxifen, raloxifene, or bazedoxifene.{{Cite journal |vauthors=Pickar JH, Boucher M, Morgenstern D |date=September 2018 |title=Tissue selective estrogen complex (TSEC): a review |journal=Menopause |volume=25 |issue=9 |pages=1033–1045 |doi=10.1097/GME.0000000000001095 |pmc=6110370 |pmid=29533367}} It is thought to have different tissue pattern of estrogenic and antiestrogenic effects than that of either the estrogen or the SERM alone. An example of a clinically used TSEC is conjugated estrogens/bazedoxifene (brand name Duavee).{{Cite journal |vauthors=Lello S, Capozzi A, Scambia G |date=2017 |title=The Tissue-Selective Estrogen Complex (Bazedoxifene/Conjugated Estrogens) for the Treatment of Menopause |journal=Int J Endocrinol |volume=2017 |pages=5064725 |doi=10.1155/2017/5064725 |pmc=5735652 |pmid=29358948 |doi-access=free}}