Toby Gibson

{{short description|British biochemist}}

{{For|the boxer|Tolman Gibson}}

{{Infobox scientist

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| name = Toby Gibson

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| birth_name = Toby James Gibson

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| fields = Computational biology
Bioinformatics
Short linear motifs
Protein interactions
Sequence alignment

| workplaces = Laboratory of Molecular Biology
European Molecular Biology Laboratory

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| education =

| alma_mater = University of Edinburgh (BSc)
University of Cambridge (PhD)

| thesis_title = Studies on the Epstein-Barr virus genome

| thesis_url = https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.352786

| thesis_year = 1984

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| known_for = Clustal{{cite journal|last1=Thompson|first1=Julie D.|last2=Higgins|first2=Desmond G.|author-link2=Desmond G. Higgins|last3=Gibson|first3=Toby J.|title=CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice|journal=Nucleic Acids Research|volume=22|issue=22|year=1994|pages=4673–4680|issn=0305-1048|doi=10.1093/nar/22.22.4673|pmid=7984417 |pmc=308517 }}

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| website = {{URL|https://www.embl.de/research/units/scb/gibson}}

}}Toby James Gibson is a group leader and biochemist at the European Molecular Biology Laboratory (EMBL) in Heidelberg{{Google scholar id}}{{EuropePMC}} known for his work on Clustal.{{cite journal|last1=Thompson|first1=J.|title=The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools|journal=Nucleic Acids Research|volume=25|issue=24|year=1997|pages=4876–4882|issn=1362-4962|doi=10.1093/nar/25.24.4876|pmid= 9396791 |pmc=147148 }} According to Nature, Gibson's co-authored papers describing Clustal{{Cite journal

| last1 = Thompson | first1 = J. D.

| last2 = Higgins | first2 = D. G.

| last3 = Gibson | first3 = T. J. |author-link3= Toby Gibson

| title = CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

| journal = Nucleic Acids Research

| volume = 22

| issue = 22

| pages = 4673–4680

| year = 1994

| pmid = 7984417

| pmc = 308517

| doi=10.1093/nar/22.22.4673

}} are among the top ten most highly cited scientific papers of all time.{{Cite journal | doi = 10.1038/514550a| pmid = 25355343| title = The top 100 papers: Nature explores the most-cited research of all time| journal = Nature| volume = 514| issue = 7524| pages = 550–3| year = 2014| last1 = Van Noorden | first1 = R. | last2 = Maher | first2 = B. | last3 = Nuzzo | first3 = R.|author3-link= Regina Nuzzo | doi-access = free}}

Education

Gibson was educated at the University of Edinburgh{{cite web|archive-url=https://web.archive.org/web/20190705185224/https://rtg2467.uni-halle.de/scientific-advisory-board/toby-james-gibson/|author=Anon|year=2019|archive-date=2019-07-05|url=https://rtg2467.uni-halle.de/scientific-advisory-board/toby-james-gibson/|website=uni-halle.de|title=Toby (James) Gibson: EMBL, Heidelberg, Germany|publisher=Martin Luther University of Halle-Wittenberg}} and went on to his PhD at the University of Cambridge in 1984 on the genome of the Epstein–Barr virus{{cite thesis|degree=PhD|publisher=University of Cambridge|url=https://idiscover.lib.cam.ac.uk/permalink/f/t9gok8/44CAM_ALMA21428137870003606|title=Studies on the Epstein-Barr virus genome|first= Toby James|last=Gibson|date=1984|id={{EThOS|uk.bl.ethos.352786}}|website=cam.ac.uk|oclc=499859334}} while working in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).

Career and research

Gibson was a postdoctoral research fellow with Sydney Brenner before moving to EMBL in 1986. He was appointed a staff scientist in 1991 and a team leader in 1996 where he has worked since.

Gibson’s research interests are in computational biology, bioinformatics, short linear motifs, protein–protein interactions and biological sequence alignment. His laboratory developed and hosts the Eukaryotic Linear Motif (ELM) resource.{{cite journal|last1=Kumar|first1=Manjeet|last2=Gouw|first2=Marc|last3=Michael|first3=Sushama|last4=Sámano-Sánchez|first4=Hugo|last5=Pancsa|first5=Rita|last6=Glavina|first6=Juliana|last7=Diakogianni|first7=Athina|last8=Valverde|first8=Jesús Alvarado|last9=Bukirova|first9=Dayana|last10=Čalyševa|first10=Jelena|last11=Palopoli|first11=Nicolas|last12=Davey|first12=Norman E|last13=Chemes|first13=Lucía B|last14=Gibson|first14=Toby J|title=ELM—the eukaryotic linear motif resource in 2020|journal=Nucleic Acids Research|year=2019|issn=0305-1048|doi=10.1093/nar/gkz1030|pmid= 31680160|doi-access=free|pmc=7145657}}

References