Togavirus 5′ plus strand cis-regulatory element

{{Infobox rfam

| Name = Togavirus 5′ plus strand cis-regulatory element

| image = RF00470.jpg

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| caption = Predicted secondary structure and sequence conservation of Toga_5_CRE

| Symbol = Toga_5_CRE

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| Rfam = RF00470

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| RNA_type = Cis-reg

| Tax_domain = Viruses

| GO =

| SO = {{SO|0000233}}

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The Togavirus 5′ plus strand cis-regulatory element is an RNA element which is thought to be essential for both plus and minus strand RNA synthesis.{{cite journal | vauthors = Frolov I, Hardy R, Rice CM | title = Cis-acting RNA elements at the 5′ end of Sindbis virus genome RNA regulate minus- and plus-strand RNA synthesis | journal = RNA | volume = 7 | issue = 11 | pages = 1638–1651 | date = November 2001 | pmid = 11720292 | pmc = 1370205 | doi = 10.1017/S135583820101010X }}

Genus Alphavirus belongs to the family Togaviridae. Alpha viruses contain secondary structural motifs in the 5′ UTR that allow them to avoid detection by IFIT1.{{cite journal | vauthors = Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS | title = A viral RNA structural element alters host recognition of nonself RNA | journal = Science | volume = 343 | issue = 6172 | pages = 783–787 | date = February 2014 | pmid = 24482115 | pmc = 4209899 | doi = 10.1126/science.1248465 }}