Traditional serrated adenoma
{{Infobox medical condition (new)
| name = Traditional serrated adenomas
| image = Traditional serrated adenoma intermed mag.jpg
| caption = Traditional serrated adenoma with intermediate magnification, showing serrated crypts and cytologic atypia (H&E stain).
| pronounce =
| field = Gastroenterology
| synonyms =
| symptoms = Asymptomatic
| complications = Colorectal cancer
| onset = >50 years of age
| duration =
| types =
| causes =
| risks =
| diagnosis = Colonoscopy
| differential =
| prevention =
| treatment = Polypectomy
| medication =
| prognosis =
| frequency = <1% of all colon polyps
| deaths =
}}
Traditional serrated adenoma is a premalignant type of polyp found in the colon, often in the distal colon (sigmoid, rectum). Traditional serrated adenomas are a type of serrated polyp, and may occur sporadically or as a part of serrated polyposis syndrome. Traditional serrated adenomas are relatively rare, accounting for less than 1% of all colon polyps.{{cite journal |last1=Kalimuthu |first1=Sangeetha N. |last2=Chelliah |first2=Adeline |last3=Chetty |first3=Runjan |title=From traditional serrated adenoma to tubulovillous adenoma and beyond |journal=World Journal of Gastrointestinal Oncology |date=15 December 2016 |volume=8 |issue=12 |pages=805–809 |doi=10.4251/wjgo.v8.i12.805 |pmid=28035250 |pmc=5156846 |issn=1948-5204 |doi-access=free }} Usually, traditional serrated adenomas are found in the distal colon and are usually less than 10 mm in size.
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Histopathology
Epidemiology
Usually found in individuals over the age of 50 years, traditional serrated adenomas affect men and women equally.{{cite journal |last1=McCarthy |first1=AJ |last2=Serra |first2=S |last3=Chetty |first3=R |title=Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis. |journal=BMJ Open Gastroenterology |date=2019 |volume=6 |issue=1 |pages=e000317 |doi=10.1136/bmjgast-2019-000317 |pmid=31413858|pmc=6673762 }} The overall prevalence of traditional serrated adenomas is less than 1% of the general population.{{cite journal |last1=Crockett |first1=SD |last2=Nagtegaal |first2=ID |title=Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia. |journal=Gastroenterology |date=October 2019 |volume=157 |issue=4 |pages=949–966.e4 |doi=10.1053/j.gastro.2019.06.041 |pmid=31323292|doi-access=free }} Traditional serrated adenomas are the least common type of serrated polyps found in the colon, accounting for 5% of serrated colon polyps.{{cite journal |last1=Chetty |first1=R |title=Traditional serrated adenoma (TSA): morphological questions, queries and quandaries. |journal=Journal of Clinical Pathology |date=January 2016 |volume=69 |issue=1 |pages=6–11 |doi=10.1136/jclinpath-2015-203452 |pmid=26553935|s2cid=12982470 |doi-access=free }}