Transaldolase 1

Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008].

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• {{cite journal |vauthors=Grossman CE, Qian Y, Banki K, Perl A |title=ZNF143 mediates basal and tissue-specific expression of human transaldolase |journal=J. Biol. Chem. |volume=279 |issue=13 |pages=12190–205 |year=2004 |pmid=14702349 |doi=10.1074/jbc.M307039200 |doi-access=free }}
• {{cite journal |vauthors=Huang JB, Espinoza J, Romero R, Petty HR |title=Transaldolase is part of a supramolecular complex containing glucose-6-phosphate dehydrogenase in human neutrophils that undergoes retrograde trafficking during pregnancy |journal=Metab. Clin. Exp. |volume=54 |issue=8 |pages=1027–33 |year=2005 |pmid=16092052 |doi=10.1016/j.metabol.2005.03.005 }}
• {{cite journal |vauthors=Valayannopoulos V, Verhoeven NM, Mention K, Salomons GS, Sommelet D, Gonzales M, Touati G, de Lonlay P, Jakobs C, Saudubray JM |title=Transaldolase deficiency: a new cause of hydrops fetalis and neonatal multi-organ disease |journal=J. Pediatr. |volume=149 |issue=5 |pages=713–7 |year=2006 |pmid=17095351 |doi=10.1016/j.jpeds.2006.08.016 }}
• {{cite journal |vauthors=Silberstein M, Landon MR, Wang YE, Perl A, Vajda S |title=Computational methods for functional site identification suggest a substrate access channel in transaldolase |journal=Genome Inform |volume=17 |issue=1 |pages=13–22 |year=2006 |pmid=17503352 }}
• {{cite journal |vauthors=Wamelink MM, Smith DE, Jansen EE, Verhoeven NM, Struys EA, Jakobs C |title=Detection of transaldolase deficiency by quantification of novel seven-carbon chain carbohydrate biomarkers in urine |journal=J. Inherit. Metab. Dis. |volume=30 |issue=5 |pages=735–42 |year=2007 |pmid=17603756 |doi=10.1007/s10545-007-0590-2 |s2cid=22549126 }}
• {{cite journal |vauthors=Wamelink MM, Struys EA, Salomons GS, Fowler D, Jakobs C, Clayton PT |title=Transaldolase deficiency in a two-year-old boy with cirrhosis |journal=Mol. Genet. Metab. |volume=94 |issue=2 |pages=255–8 |year=2008 |pmid=18331807 |doi=10.1016/j.ymgme.2008.01.011 }}
• {{cite journal |vauthors=Qian Y, Banerjee S, Grossman CE, Amidon W, Nagy G, Barcza M, Niland B, Karp DR, Middleton FA, Banki K, Perl A |title=Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing |journal=Biochem. J. |volume=415 |issue=1 |pages=123–34 |year=2008 |pmid=18498245 |doi=10.1042/BJ20080722 }}
• {{cite journal |vauthors=Schneider S, Sandalova T, Schneider G, Sprenger GA, Samland AK |title=Replacement of a phenylalanine by a tyrosine in the active site confers fructose-6-phosphate aldolase activity to the transaldolase of Escherichia coli and human origin |journal=J. Biol. Chem. |volume=283 |issue=44 |pages=30064–72 |year=2008 |pmid=18687684 |pmc=2662071 |doi=10.1074/jbc.M803184200 |doi-access=free }}
• {{cite journal |vauthors=Basta PV, Bensen JT, Tse CK, Perou CM, Sullivan PF, Olshan AF |title=Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck |journal=Cancer Detect. Prev. |volume=32 |issue=3 |pages=200–8 |year=2008 |pmid=18805652 |pmc=2614275 |doi=10.1016/j.cdp.2008.08.008 }}

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