Transportin-3

TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.

The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.{{cite journal |vauthors=Radstake TR, Gorlova O, Rueda B, etal | title = Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus | journal = Nat. Genet. | volume = 42 | issue = 5 | pages = 426–9 |date=May 2010 | pmid = 20383147 | doi = 10.1038/ng.565 | pmc=2861917}}

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