Trazium

{{Short description|Chemical compound}}

{{this|an antidepressant|the antibiotic with the trade name Trazium|ceftriaxone}}

{{Drugbox

| IUPAC_name = 1-(4-Chlorophenyl)-1-hydroxy-1,4-dihydro[1,2,4]triazino[6,1-a]isoquinolin-5-ium

| image = Trazium.png

| image_class = skin-invert-image

| INN = Trazium esilate

| tradename =

| pregnancy_category =

| legal_status = Uncontrolled

| routes_of_administration = Oral

| bioavailability =

| metabolism =

| elimination_half-life =

| excretion =

| CAS_number = 97110-59-3

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 1PO9LWW5IN

| ATC_prefix = none

| ATC_suffix =

| PubChem = 72166

| ChemSpiderID = 65139

| C=17 | H=13 | Cl=1 | N=3 | O=1

}}

Trazium (EGYT-3,615) is an antidepressant drug which was never marketed.{{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 | isbn = 0-412-46630-9 | url = https://books.google.com/books?id=A0THacd46ZsC&q=trazium&pg=PA2013}} It has psychostimulant-like effects and its actions appear to be mediated by the dopaminergic and adrenergic systems.{{cite journal |vauthors=Gyertyán I, Petöcz L, Bajnógel J, etal | title = Possible involvement of the dopaminergic system in the mode of action of the potential antidepressant trazium esilate | journal = Arzneimittel-Forschung | volume = 39 | issue = 7 | pages = 775–81 |date=July 1989 | pmid = 2551306 }} It was formulated as a salt with ethanesulfonic acid and given the generic name trazium esilate (INN).{{cite web | url = http://www.chemspider.com/Chemical-Structure.65139.htm | title = Trazium Esilate | publisher = ChemSpider }}{{Dead link|date=March 2024 |bot=InternetArchiveBot |fix-attempted=yes }}