Trichodiene synthase

{{infobox enzyme

| Name = trichodiene synthase

| EC_number = 4.2.3.6

| CAS_number = 101915-76-8

| GO_code = 0045482

| image =

| width =

| caption =

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The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction

:(2E,6E)-farnesyl diphosphate $\rightleftharpoons$ trichodiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1YJ4}}, {{PDB link|1YYQ}}, {{PDB link|1YYR}}, {{PDB link|1YYS}}, {{PDB link|1YYT}}, {{PDB link|1YYU}}, {{PDB link|2AEK}}, {{PDB link|2AEL}}, and {{PDB link|2AET}}.

References

{{cite journal | vauthors = Hohn TM, Vanmiddlesworth F | date = 1986 | title = Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides | journal = Arch. Biochem. Biophys. | volume = 251 | pages = 756–61 | pmid = 3800398 | doi = 10.1016/0003-9861(86)90386-3 | issue = 2 | url = https://naldc-legacy.nal.usda.gov/naldc/download.xhtml?id=23897&content=PDF | url-access = subscription }}{{dead link|date=June 2025|bot=medic}}{{cbignore|bot=medic}}

Category:EC 4.2.3

Category:Enzymes of known structure