Trimethoprim/polymyxin B

{{Short description|Combination drug}}

{{Use dmy dates|date=December 2024}}

{{cs1 config|name-list-style=vanc|display-authors=6}}

{{Infobox drug

| verifiedrevid = 451334370

| type = combo

| component1 = Polymyxin B

| class1 = Cell envelope antibiotic

| component2 = Trimethoprim

| class2 = Nucleic acid inhibitor antibiotic

| tradename = Polytrim

| pregnancy_AU =

| pregnancy_category =

| dependency_liability =

| routes_of_administration = Topical eye drops

| ATC_prefix = S01

| ATC_suffix = AA30

| legal_AU =

| legal_CA =

| legal_UK =

| legal_US = Rx only

| legal_US_comment = {{cite web | title=Polytrim (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) Sterile | website=DailyMed | url=https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=652205 | access-date=6 December 2024}}

| legal_status =

| CAS_number = 103172-75-4

| PubChem = 24848162

| DrugBank_Ref =

| KEGG_Ref = {{keggcite|correct|kegg}}

| KEGG = D11086

| synonyms =

}}

Polymyxin B/trimethoprim, sold under the brand name Polytrim is an antimicrobial solution for topical ophthalmic use in the treatment of acute bacterial conjunctivitis and blepharoconjunctivitis.

In 2022, it was the 252nd most commonly prescribed medication in the United States, with more than 1{{nbsp}}million prescriptions.{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}{{cite web | title = Polymyxin B; Trimethoprim Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/PolymyxinBTrimethoprim | access-date = 30 August 2024 }}