Tripotassium phosphate

{{chembox

| Watchedfields = changed

| verifiedrevid = 442343633

| ImageFile = Tripotassium phosphate.png

| ImageSize = 150px

| ImageFile1 = Kaliumphosphat.png

| ImageSize1 = 240px

| ImageCaption1 = Unit cell of tripotassium phosphate.

| ImageAlt1 = Unit cell of the anhydrous tripotassium phosphate under standard conditions (low temperature modification).

| IUPACName = Potassium phosphate

| SystematicName = Potassium tetraoxidophosphate(3−)

| OtherNames = Potassium phosphate, tribasic

|Section1={{Chembox Identifiers

| CASNo = 7778-53-2

| CASNo_Ref = {{cascite|correct|CAS}}

| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}

| ChemSpiderID = 56408

| ChEBI = 190301

| EC_number = 231-907-1

| PubChem = 62657

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 16D59922JU

| SMILES = [K+].[K+].[K+].[O-]P([O-])([O-])=O

| StdInChI_Ref = {{stdinchicite|correct|chemspider}}

| StdInChI = 1S/3K.H3O4P/c;;;1-5(2,3)4/h;;;(H3,1,2,3,4)/q3*+1;/p-3

| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}

| StdInChIKey = LWIHDJKSTIGBAC-UHFFFAOYSA-K

}}

|Section2={{Chembox Properties

| Formula = K3PO4

| MolarMass = 212.27 g/mol

| Appearance = White deliquescent powder

| Density = 2.564 g/cm3 (17 °C)

| MeltingPtC = 1380

| BoilingPt =

| Solubility = 90 g/100 mL (20 °C)

| SolubleOther = Insoluble

| Solvent = ethanol

| pKb = 1.6

}}

|Section3={{Chembox Structure

| Structure_ref = {{Cite journal | doi=10.1134/S0020168506080206|title = Crystal structure of the low-temperature form of K3PO4| journal=Inorganic Materials| volume=42| issue=8| pages=908–913|year = 2006|last1 = Voronin|first1 = V. I.| last2=Ponosov| first2=Yu. S.| last3=Berger| first3=I. F.| last4=Proskurnina| first4=N. V.| last5=Zubkov| first5=V. G.| last6=Tyutyunnik| first6=A. P.| last7=Bushmeleva| first7=S. N.| last8=Balagurov| first8=A. M.| last9=Sheptyakov| first9=D. V.| last10=Burmakin| first10=E. I.| last11=Shekhtman| first11=G. Sh.| last12=Vovkotrub| first12=E. G.|s2cid = 92351896}}

| CrystalStruct = Primitive orthorhombic

| LattConst_a = 1.123772 nm

| LattConst_b = 0.810461 nm

| LattConst_c = 0.592271 nm

| LattConst_ref =

| SpaceGroup = Pnma, No. 62

}}

|Section4={{Chembox Hazards

| ExternalSDS = [https://www.fishersci.com/msds?productName=P289500 MSDS]

| MainHazards = Irritant

| NFPA-H = 2

| NFPA-F = 0

| NFPA-R = 0

| NFPA-S =

| Hazards_ref={{cite web |title=Potassium phosphate |url=https://pubchem.ncbi.nlm.nih.gov/compound/62657#section=Safety-and-Hazards |website=pubchem.ncbi.nlm.nih.gov |language=en}}

| GHSPictograms = {{GHS07}}

| GHSSignalWord = Warning

| HPhrases = {{H-phrases|319}}

| PPhrases = {{P-phrases|264|280|305+351+338|337+313}}

| FlashPt = Non-flammable

}}

|Section8={{Chembox Related

| OtherAnions =

| OtherCations = Trisodium phosphate
Triammonium phosphate
Tricalcium phosphate

| OtherCompounds = Monopotassium phosphate
Dipotassium phosphate

}}

}}

Tripotassium phosphate, also called tribasic potassium phosphate{{Cite web|url=https://www.sigmaaldrich.com/catalog/product/SIAL/P5629?lang=en®ion=US&gclid=CjwKCAjwhcjVBRBHEiwAoDe5x4mgjw3D-Q3p-5HkZkBQX2hrkJZmUDb5Qt6FndG1g9fBXnUtTjM26BoC1WQQAvD_BwE|title=Potassium phosphate tribasic P5629|website=Sigma-Aldrich|access-date=2018-04-27}} is a water-soluble salt with the chemical formula K3PO4.(H2O)x (x = 0, 3, 7, 9).{{Ullmann|author1=Klaus Schrödter|author2=Gerhard Bettermann|author3=Thomas Staffel|author4=Friedrich Wahl|author5=Thomas Klein|author6=Thomas Hofmann|title=Phosphoric Acid and Phosphates|doi=10.1002/14356007.a19_465.pub3|year=2012}} Tripotassium phosphate is basic: a 1% aqueous solution has a pH of 11.8.

Production

Tripotassium phosphate is produced by the neutralization of phosphoric acid with potassium hydroxide:

:{{chem2|H3PO4 + 3KOH -> K3PO4 + 3H2O}}

Use in organic chemistry

File:K3PO4.jpg

Tripotassium phosphate has few industrial applications, however it is commonly used as a base in laboratory-scale organic chemistry. Being insoluble in organic solvents, it is an easily removed proton acceptor in organic synthesis. The anhydrous salt is especially basic.{{cite book |doi=10.1002/047084289X.rn01172 |chapter=Potassium Phosphate |title=Encyclopedia of Reagents for Organic Synthesis |date=2010 |last1=Chiong |first1=Hendrich A. |isbn=978-0-471-93623-7 }} Some of the reactions are listed below:

  1. The hydrate ({{chem2|K3PO4*H2O}}) has been used to catalyze the deprotection of BOC amines. Microwave radiation is used to aid the reaction.{{Cite journal|date=2009-03-04|title=Microwave-assisted N-Boc deprotection under mild basic conditions using K3PO4·H2O in MeOH|journal=Tetrahedron Letters|language=en|volume=50|issue=9|pages=1071–1074|doi=10.1016/j.tetlet.2008.12.074|issn=0040-4039|last1=Dandepally|first1=Srinivasa Reddy|last2=Williams|first2=Alfred L.}}
  2. As a catalyst for the synthesis of unsymmetrical diaryl ethers using [Bmim]BF4 as the solvent. Aryl methane-sulfonates are deprotected and then followed by a nucleophilic aromatic substitution (SNAr) with activated aryl halides.{{Cite journal|last1=Xu|first1=Hui|last2=Chen|first2=Yang|date=2007-04-30|title=C(aryl)-O Bond Formation from Aryl Methanesulfonates via Consecutive Deprotection and SNAr Reactions with Aryl Halides in an Ionic Liquid|journal=Molecules|language=en|volume=12|issue=4|pages=861–867|doi=10.3390/12040861|pmid=17851438|pmc=6149384|doi-access=free}}
  3. As a base in the cross-coupling reaction of aryl halides with terminal alkynes. It also plays a role in the deacetonation of 4-aryl-2-methylbut-3-yn-2-ol intermediates.{{Cite journal|date=2005-10-10|title=A simple catalyst system for the palladium-catalyzed coupling of aryl halides with terminal alkynes|journal=Tetrahedron|language=en|volume=61|issue=41|pages=9878–9885|doi=10.1016/j.tet.2005.07.099|issn=0040-4020|last1=Shirakawa|first1=Eiji|last2=Kitabata|first2=Takaaki|last3=Otsuka|first3=Hidehito|last4=Tsuchimoto|first4=Teruhisa}}
  4. As the base in the cross-coupling reaction between aryl halides and phenols or aliphatic alcohols.{{Cite journal|last1=Niu|first1=Jiajia|last2=Zhou|first2=Hua|last3=Li|first3=Zhigang|last4=Xu|first4=Jingwei|last5=Hu|first5=Shaojing|date=2008-10-03|title=An Efficient Ullmann-Type C−O Bond Formation Catalyzed by an Air-Stable Copper(I)−Bipyridyl Complex|journal=The Journal of Organic Chemistry|language=EN|volume=73|issue=19|pages=7814–7817|doi=10.1021/jo801002c|pmid=18771324|issn=0022-3263}}

Use in foods

Tripotassium phosphate can be used in foods as a buffering agent, emulsifying agent, and for nutrient fortification. It can serve as a sodium-free substitute for trisodium phosphate. The ingredient is most common in dry cereals but is also found in meat, sauces, and cheeses.{{Cite web |last=Han |first=James |date=2020-08-03 |title=What is Tripotassium Phosphate E340(iii) in Food and Functions in Cereals? |url=https://foodadditives.net/phosphates/tripotassium-phosphate/ |access-date=2022-12-22 |website=foodadditives.net |language=en-US}}

References