Tripotassium phosphate
{{chembox
| Watchedfields = changed
| verifiedrevid = 442343633
| ImageFile = Tripotassium phosphate.png
| ImageSize = 150px
| ImageFile1 = Kaliumphosphat.png
| ImageSize1 = 240px
| ImageCaption1 = Unit cell of tripotassium phosphate.
| ImageAlt1 = Unit cell of the anhydrous tripotassium phosphate under standard conditions (low temperature modification).
| IUPACName = Potassium phosphate
| SystematicName = Potassium tetraoxidophosphate(3−)
| OtherNames = Potassium phosphate, tribasic
|Section1={{Chembox Identifiers
| CASNo = 7778-53-2
| CASNo_Ref = {{cascite|correct|CAS}}
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 56408
| ChEBI = 190301
| EC_number = 231-907-1
| PubChem = 62657
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 16D59922JU
| SMILES = [K+].[K+].[K+].[O-]P([O-])([O-])=O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/3K.H3O4P/c;;;1-5(2,3)4/h;;;(H3,1,2,3,4)/q3*+1;/p-3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = LWIHDJKSTIGBAC-UHFFFAOYSA-K
}}
|Section2={{Chembox Properties
| Formula = K3PO4
| MolarMass = 212.27 g/mol
| Appearance = White deliquescent powder
| Density = 2.564 g/cm3 (17 °C)
| MeltingPtC = 1380
| BoilingPt =
| Solubility = 90 g/100 mL (20 °C)
| SolubleOther = Insoluble
| Solvent = ethanol
| pKb = 1.6
}}
|Section3={{Chembox Structure
| CrystalStruct = Primitive orthorhombic
| LattConst_a = 1.123772 nm
| LattConst_b = 0.810461 nm
| LattConst_c = 0.592271 nm
| SpaceGroup = Pnma, No. 62
}}
|Section4={{Chembox Hazards
| ExternalSDS = [https://www.fishersci.com/msds?productName=P289500 MSDS]
| MainHazards = Irritant
| NFPA-H = 2
| NFPA-F = 0
| NFPA-R = 0
| NFPA-S =
| GHSPictograms = {{GHS07}}
| GHSSignalWord = Warning
| HPhrases = {{H-phrases|319}}
| PPhrases = {{P-phrases|264|280|305+351+338|337+313}}
| FlashPt = Non-flammable
}}
|Section8={{Chembox Related
| OtherAnions =
| OtherCations = Trisodium phosphate
Triammonium phosphate
Tricalcium phosphate
| OtherCompounds = Monopotassium phosphate
Dipotassium phosphate
}}
}}
Tripotassium phosphate, also called tribasic potassium phosphate{{Cite web|url=https://www.sigmaaldrich.com/catalog/product/SIAL/P5629?lang=en®ion=US&gclid=CjwKCAjwhcjVBRBHEiwAoDe5x4mgjw3D-Q3p-5HkZkBQX2hrkJZmUDb5Qt6FndG1g9fBXnUtTjM26BoC1WQQAvD_BwE|title=Potassium phosphate tribasic P5629|website=Sigma-Aldrich|access-date=2018-04-27}} is a water-soluble salt with the chemical formula K3PO4.(H2O)x (x = 0, 3, 7, 9).{{Ullmann|author1=Klaus Schrödter|author2=Gerhard Bettermann|author3=Thomas Staffel|author4=Friedrich Wahl|author5=Thomas Klein|author6=Thomas Hofmann|title=Phosphoric Acid and Phosphates|doi=10.1002/14356007.a19_465.pub3|year=2012}} Tripotassium phosphate is basic: a 1% aqueous solution has a pH of 11.8.
Production
Tripotassium phosphate is produced by the neutralization of phosphoric acid with potassium hydroxide:
:{{chem2|H3PO4 + 3KOH -> K3PO4 + 3H2O}}
Use in organic chemistry
Tripotassium phosphate has few industrial applications, however it is commonly used as a base in laboratory-scale organic chemistry. Being insoluble in organic solvents, it is an easily removed proton acceptor in organic synthesis. The anhydrous salt is especially basic.{{cite book |doi=10.1002/047084289X.rn01172 |chapter=Potassium Phosphate |title=Encyclopedia of Reagents for Organic Synthesis |date=2010 |last1=Chiong |first1=Hendrich A. |isbn=978-0-471-93623-7 }} Some of the reactions are listed below:
- The hydrate ({{chem2|K3PO4*H2O}}) has been used to catalyze the deprotection of BOC amines. Microwave radiation is used to aid the reaction.{{Cite journal|date=2009-03-04|title=Microwave-assisted N-Boc deprotection under mild basic conditions using K3PO4·H2O in MeOH|journal=Tetrahedron Letters|language=en|volume=50|issue=9|pages=1071–1074|doi=10.1016/j.tetlet.2008.12.074|issn=0040-4039|last1=Dandepally|first1=Srinivasa Reddy|last2=Williams|first2=Alfred L.}}
- As a catalyst for the synthesis of unsymmetrical diaryl ethers using [Bmim]BF4 as the solvent. Aryl methane-sulfonates are deprotected and then followed by a nucleophilic aromatic substitution (SNAr) with activated aryl halides.{{Cite journal|last1=Xu|first1=Hui|last2=Chen|first2=Yang|date=2007-04-30|title=C(aryl)-O Bond Formation from Aryl Methanesulfonates via Consecutive Deprotection and SNAr Reactions with Aryl Halides in an Ionic Liquid|journal=Molecules|language=en|volume=12|issue=4|pages=861–867|doi=10.3390/12040861|pmid=17851438|pmc=6149384|doi-access=free}}
- As a base in the cross-coupling reaction of aryl halides with terminal alkynes. It also plays a role in the deacetonation of 4-aryl-2-methylbut-3-yn-2-ol intermediates.{{Cite journal|date=2005-10-10|title=A simple catalyst system for the palladium-catalyzed coupling of aryl halides with terminal alkynes|journal=Tetrahedron|language=en|volume=61|issue=41|pages=9878–9885|doi=10.1016/j.tet.2005.07.099|issn=0040-4020|last1=Shirakawa|first1=Eiji|last2=Kitabata|first2=Takaaki|last3=Otsuka|first3=Hidehito|last4=Tsuchimoto|first4=Teruhisa}}
- As the base in the cross-coupling reaction between aryl halides and phenols or aliphatic alcohols.{{Cite journal|last1=Niu|first1=Jiajia|last2=Zhou|first2=Hua|last3=Li|first3=Zhigang|last4=Xu|first4=Jingwei|last5=Hu|first5=Shaojing|date=2008-10-03|title=An Efficient Ullmann-Type C−O Bond Formation Catalyzed by an Air-Stable Copper(I)−Bipyridyl Complex|journal=The Journal of Organic Chemistry|language=EN|volume=73|issue=19|pages=7814–7817|doi=10.1021/jo801002c|pmid=18771324|issn=0022-3263}}
Use in foods
Tripotassium phosphate can be used in foods as a buffering agent, emulsifying agent, and for nutrient fortification. It can serve as a sodium-free substitute for trisodium phosphate. The ingredient is most common in dry cereals but is also found in meat, sauces, and cheeses.{{Cite web |last=Han |first=James |date=2020-08-03 |title=What is Tripotassium Phosphate E340(iii) in Food and Functions in Cereals? |url=https://foodadditives.net/phosphates/tripotassium-phosphate/ |access-date=2022-12-22 |website=foodadditives.net |language=en-US}}