Tweety family member 2

{{Short description|Protein-coding gene in the species Homo sapiens}}

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.{{cite web | title = Entrez Gene: Tweety family member 2 | url = https://www.ncbi.nlm.nih.gov/gene/94015}} Members of this family function as chloride channels. The encoded protein functions as a calcium²⁺-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.

References

{{cite journal | vauthors = Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T | title = Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor | journal = Nature Biotechnology | volume = 29 | issue = 7 | pages = 653–8 | date = June 2011 | pmid = 21706016 | doi = 10.1038/nbt.1905 | s2cid = 205275786 }}
{{cite journal | vauthors = Ibarrola N, Molina H, Iwahori A, Pandey A | title = A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 15805–13 | date = April 2004 | pmid = 14739304 | doi = 10.1074/jbc.M311714200 | doi-access = free }}
{{cite journal | vauthors = Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA |authorlink4=Grant Robert Sutherland | title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma | journal = Genomics | volume = 77 | issue = 3 | pages = 200–7 | date = October 2001 | pmid = 11597145 | doi = 10.1006/geno.2001.6629 }}
{{cite journal | vauthors = Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M | title = TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation | journal = World Journal of Gastroenterology | volume = 13 | issue = 19 | pages = 2717–21 | date = May 2007 | pmid = 17569141 | pmc = 4147121 | doi=10.3748/wjg.v13.i19.2717 | doi-access = free }}
{{cite journal | vauthors = Suzuki M, Mizuno A | title = A novel human Cl(-) channel family related to Drosophila flightless locus | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22461–8 | date = May 2004 | pmid = 15010458 | doi = 10.1074/jbc.M313813200 | doi-access = free }}
{{cite journal | vauthors = He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD | title = N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2) | journal = The Biochemical Journal | volume = 412 | issue = 1 | pages = 45–55 | date = May 2008 | pmid = 18260827 | doi = 10.1042/BJ20071722 | s2cid = 25166381 }}
{{cite journal | vauthors = He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD | title = The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels | journal = The Journal of Biological Chemistry | volume = 283 | issue = 35 | pages = 24000–10 | date = August 2008 | pmid = 18577513 | pmc = 3259790 | doi = 10.1074/jbc.M803361200 | doi-access = free }}

Tweety family member 2

See also

References

Further reading