Tyrosine-protein kinase Fes/Fps
{{Short description|Human protein and coding gene}}
{{Infobox_gene}}
Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene.{{cite journal | vauthors = Bowden DW, Akots G, Rothschild CB | title = An insertion deletion polymorphism associated with C-FES | journal = Nucleic Acids Research | volume = 19 | issue = 15 | pages = 4311 | date = Aug 1991 | pmid = 1870997 | pmc = 328602 | doi = 10.1093/nar/19.15.4311 }}{{cite web |title=FES - Tyrosine-protein kinase Fes/Fps - Homo sapiens (Human) - FES gene & protein |url=https://www.uniprot.org/uniprot/P07332 |website=www.uniprot.org |access-date=16 May 2022 |language=en}} FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.{{cite journal | vauthors = Craig AW | title = FES/FER kinase signaling in hematopoietic cells and leukemias | journal = Frontiers in Bioscience | volume = 17 | pmid = 22201778 | year=2012 | issue = 3 | pages=861–75 | doi=10.2741/3961| doi-access = free }}
Function
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.{{cite web | title = Entrez Gene: FES feline sarcoma oncogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2242}}
Interactions
Feline sarcoma oncogene has been shown to interact with BCAR1{{cite journal | vauthors = Jücker M, McKenna K, da Silva AJ, Rudd CE, Feldman RA | title = The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signaling | journal = The Journal of Biological Chemistry | volume = 272 | issue = 4 | pages = 2104–9 | date = Jan 1997 | pmid = 8999909 | doi = 10.1074/jbc.272.4.2104 | doi-access = free }} and BCR gene.{{cite journal | vauthors = Lionberger JM, Smithgall TE | title = The c-Fes protein-tyrosine kinase suppresses cytokine-independent outgrowth of myeloid leukemia cells induced by Bcr-Abl | journal = Cancer Research | volume = 60 | issue = 4 | pages = 1097–103 | date = Feb 2000 | pmid = 10706130 }}{{cite journal | vauthors = Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE | title = Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS | journal = Molecular and Cellular Biology | volume = 15 | issue = 2 | pages = 835–42 | date = Feb 1995 | pmid = 7529874 | pmc = 231961 | doi=10.1128/MCB.15.2.835}}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Smithgall TE, Rogers JA, Peters KL, Li J, Briggs SD, Lionberger JM, Cheng H, Shibata A, Scholtz B, Schreiner S, Dunham N | title = The c-Fes family of protein-tyrosine kinases | journal = Critical Reviews in Oncogenesis | volume = 9 | issue = 1 | pages = 43–62 | year = 1998 | pmid = 9754447 | doi = 10.1615/critrevoncog.v9.i1.40 }}
- {{cite journal | vauthors = Jiang H, Harris MB, Rothman P | title = IL-4/IL-13 signaling beyond JAK/STAT | journal = The Journal of Allergy and Clinical Immunology | volume = 105 | issue = 6 Pt 1 | pages = 1063–70 | date = Jun 2000 | pmid = 10856136 | doi = 10.1067/mai.2000.107604 | doi-access = free }}
- {{cite journal | vauthors = Greer P | title = Closing in on the biological functions of Fps/Fes and Fer | journal = Nature Reviews Molecular Cell Biology | volume = 3 | issue = 4 | pages = 278–89 | date = Apr 2002 | pmid = 11994747 | doi = 10.1038/nrm783 | s2cid = 22927394 }}
{{refend}}
External links
- {{PDBe-KB2|P07332|Tyrosine-protein kinase Fes/Fps}}
{{PDB Gallery|geneid=2242}}
{{Tyrosine kinases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}
{{gene-15-stub}}