U7 small nuclear RNA
{{Infobox rfam
| Name = U7 small nuclear RNA
| image = RF00066.jpg
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| caption = Predicted secondary structure and sequence conservation of U7
| Symbol = U7
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| Rfam = RF00066
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| Tax_domain = Eukaryota
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| SO = {{SO|0000274}}
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The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing.
The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.{{cite journal |vauthors=Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D |title=3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA |journal=Nucleic Acids Res |volume=22 |pages=4023–4030 |year=1994 |pmid=7937126| doi = 10.1093/nar/22.20.4023 | issue = 20 | pmc = 331885}}{{cite journal |vauthors=Mowry KL, Steitz JA |title=Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's |journal=Science |volume=238 |issue=4834 |pages=1682–1687 |year=1987 |pmid=2825355| doi = 10.1126/science.2825355|bibcode=1987Sci...238.1682M }} The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.{{Cite journal|last1=Marzluff|first1=William F.|last2=Wagner|first2=Eric J.|last3=Duronio|first3=Robert J.|title=Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail|journal=Nature Reviews Genetics|volume=9|issue=11|pages=843–854|doi=10.1038/nrg2438|pmc=2715827|pmid=18927579|year=2008}}
See also
References
{{Reflist}}
Further reading
External links
- {{Rfam|id=RF00066|name=U7 small nuclear RNA}}
- [http://rnp.uthscsa.edu/index.html/ The uRNA database]