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UACA

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{distinguish|Uaçá River}}

{{Infobox_gene}}

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.{{cite journal | vauthors = Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, Ohno S, Negi A, Nishimura Y | display-authors = 6 | title = Identification of a novel autoantigen UACA in patients with panuveitis | journal = Biochemical and Biophysical Research Communications | volume = 280 | issue = 4 | pages = 1169–1176 | date = February 2001 | pmid = 11162650 | doi = 10.1006/bbrc.2001.4189 }}{{cite journal | vauthors = Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 4 | pages = 273–281 | date = August 2000 | pmid = 10997877 | doi = 10.1093/dnares/7.4.271 | doi-access = free }}{{cite web | title = Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55075}} Diseases associated with UACA include Graves' Disease.{{cite journal | vauthors = Ohkura T, Taniguchi S, Yamada K, Nishio N, Okamura T, Yoshida A, Kamijou K, Fukata S, Kuma K, Inoue Y, Hisatome I, Senju S, Nishimura Y, Shigemasa C | display-authors = 6 | title = Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease | journal = Biochemical and Biophysical Research Communications | volume = 321 | issue = 2 | pages = 432–440 | date = August 2004 | pmid = 15358194 | doi = 10.1016/j.bbrc.2004.06.162 }} Among its related pathways are signaling by Rho GTPases and Intrinsic Pathway for Apoptosis. An important paralog of this gene is ANKRD24.{{Cite web |title=UniProt |url=https://www.uniprot.org/uniprotkb/Q8TF21/ent |access-date=2023-06-07 |website=www.uniprot.org}}

References

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Further reading

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  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
  • {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–1784 | date = November 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
  • {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | display-authors = 6 | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 | name-list-style = vanc | s2cid = 11683986 }}
  • {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | display-authors = 6 | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–716 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | name-list-style = vanc | s2cid = 27764390 }}
  • {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | display-authors = 6 | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–12135 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 | name-list-style = vanc | doi-access = free | bibcode = 2004PNAS..10112130B }}

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