UBE2D3

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.

UBE2D3 has been shown to interact with NEDD4.{{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes to Cells | volume = 3 | issue = 11 | pages = 751–63 | date = Nov 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x | s2cid = 1653536 }}{{cite journal | vauthors = Wang X, Shi Y, Wang J, Huang G, Jiang X | title = Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradation | journal = The Biochemical Journal | volume = 414 | issue = 2 | pages = 221–9 | date = Sep 2008 | pmid = 18498243 | doi = 10.1042/BJ20080674 }}

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• {{cite journal | vauthors = Scheffner M, Huibregtse JM, Howley PM | title = Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 19 | pages = 8797–801 | date = Sep 1994 | pmid = 8090726 | pmc = 44693 | doi = 10.1073/pnas.91.19.8797 | bibcode = 1994PNAS...91.8797S | doi-access = free }}
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• {{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes to Cells | volume = 3 | issue = 11 | pages = 751–63 | date = Nov 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x | s2cid = 1653536 }}
• {{cite journal | vauthors = Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A | title = Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha | journal = The Journal of Biological Chemistry | volume = 274 | issue = 21 | pages = 14823–30 | date = May 1999 | pmid = 10329681 | doi = 10.1074/jbc.274.21.14823 | doi-access = free }}
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• {{cite journal | vauthors = Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA | title = The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 24 | pages = 21930–7 | date = Jun 2003 | pmid = 12670957 | doi = 10.1074/jbc.M301157200 | doi-access = free }}
• {{cite journal | vauthors = Brzovic PS, Keeffe JR, Nishikawa H, Miyamoto K, Fox D, Fukuda M, Ohta T, Klevit R | title = Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 10 | pages = 5646–51 | date = May 2003 | pmid = 12732733 | pmc = 156255 | doi = 10.1073/pnas.0836054100 | bibcode = 2003PNAS..100.5646B | doi-access = free }}
• {{cite journal | vauthors = Tang ED, Wang CY, Xiong Y, Guan KL | title = A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha | journal = The Journal of Biological Chemistry | volume = 278 | issue = 39 | pages = 37297–305 | date = Sep 2003 | pmid = 12867425 | doi = 10.1074/jbc.M303389200 | doi-access = free }}
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• {{cite journal | vauthors = Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP | title = Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 42169–81 | date = Oct 2004 | pmid = 15280377 | doi = 10.1074/jbc.M403362200 | doi-access = free }}
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• {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}

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{{PDB Gallery|geneid=7323}}

{{Ubiquitin-conjugating enzymes}}

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