UBL5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Ubiquitin-like protein 5 is a protein that in humans is encoded by the UBL5 gene.{{cite web | title = Entrez Gene: UBL5 ubiquitin-like 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59286}}
It has been shown that in C. elegans mitochondria treated to lower expression of certain electron transport chain proteins during the L3/L4 stage, its expression levels is higher leading to increased lifespans.Mitochondrial Stress Signals
Revise an Old Aging Theory - DOI 10.1016/j.cell.2010.12.023
Ubiquitin-like proteins (UBLs) are thought to be reversible modulators of protein function rather than protein degraders like ubiquitin (MIM 191339).[supplied by OMIM]
References
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Further reading
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- {{cite journal | vauthors=Friedman JS, Koop BF, Raymond V, Walter MA |title=Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes |journal=Genomics |volume=71 |issue= 2 |pages= 252–5 |year= 2001 |pmid= 11161819 |doi= 10.1006/geno.2000.6439 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Kantham L, Kerr-Bayles L, Godde N, etal |title=Beacon interacts with cdc2/cdc28-like kinases |journal=Biochem. Biophys. Res. Commun. |volume=304 |issue= 1 |pages= 125–9 |year= 2003 |pmid= 12705895 |doi=10.1016/S0006-291X(03)00549-7 }}
- {{cite journal |vauthors=McNally T, Huang Q, Janis RS, etal |title=Structural analysis of UBL5, a novel ubiquitin-like modifier |journal=Protein Sci. |volume=12 |issue= 7 |pages= 1562–6 |year= 2004 |pmid= 12824502 |doi=10.1110/ps.0382803 | pmc=2323916 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Wilkinson CR, Dittmar GA, Ohi MD, etal |title=Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast |journal=Curr. Biol. |volume=14 |issue= 24 |pages= 2283–8 |year= 2005 |pmid= 15620657 |doi= 10.1016/j.cub.2004.11.058 |doi-access= free }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
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External links
- {{PDBe-KB2|Q9BZL1|Human Ubiquitin-like protein 5}}
- {{PDBe-KB2|Q9EPV8|Mouse Ubiquitin-like protein 5}}
{{PDB Gallery|geneid=59286}}
{{gene-19-stub}}