UBR5

This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.

UBR5 has been shown to interact with:

• CIB1,{{cite journal | vauthors = Henderson MJ, Russell AJ, Hird S, Muñoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK | title = EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response | journal = J. Biol. Chem. | volume = 277 | issue = 29 | pages = 26468–78 | date = Jul 2002 | pmid = 12011095 | doi = 10.1074/jbc.M203527200 | doi-access = free | hdl = 1885/64590 | hdl-access = free }}
• Karyopherin alpha 1,
• MAPK1,{{cite journal | vauthors = Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ | title = Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 14926–35 | date = Apr 2003 | pmid = 12594221 | doi = 10.1074/jbc.M300485200 | doi-access = free }} and
• TOPBP1.{{cite journal | vauthors = Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M, Saya H, Nakao M | title = Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3599–605 | date = Feb 2002 | pmid = 11714696 | doi = 10.1074/jbc.M104347200 | doi-access = free }}

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• {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | doi-access = free }}
• {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 | year = 1999 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 | doi-access = free }}
• {{cite journal | vauthors = Deo RC, Sonenberg N, Burley SK | title = X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 8 | pages = 4414–9 | year = 2001 | pmid = 11287654 | pmc = 31849 | doi = 10.1073/pnas.071552198 | doi-access = free }}
• {{cite journal | vauthors = Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M, Saya H, Nakao M | title = Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response | journal = J. Biol. Chem. | volume = 277 | issue = 5 | pages = 3599–605 | year = 2002 | pmid = 11714696 | doi = 10.1074/jbc.M104347200 | doi-access = free }}
• {{cite journal | vauthors = Henderson MJ, Russell AJ, Hird S, Muñoz M, Clancy JL, Lehrbach GM, Calanni ST, Jans DA, Sutherland RL, Watts CK | title = EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response | journal = J. Biol. Chem. | volume = 277 | issue = 29 | pages = 26468–78 | year = 2002 | pmid = 12011095 | doi = 10.1074/jbc.M203527200 | doi-access = free | hdl = 1885/64590 | hdl-access = free }}
• {{cite journal | vauthors = Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ | title = Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs | journal = J. Biol. Chem. | volume = 278 | issue = 17 | pages = 14926–35 | year = 2003 | pmid = 12594221 | doi = 10.1074/jbc.M300485200 | doi-access = free }}
• {{cite journal | vauthors = Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN | title = Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35325–36 | year = 2003 | pmid = 12840015 | doi = 10.1074/jbc.M305191200 | doi-access =free }}
• {{cite journal | vauthors = Clancy JL, Henderson MJ, Russell AJ, Anderson DW, Bova RJ, Campbell IG, Choong DY, Macdonald GA, Mann GJ, Nolan T, Brady G, Olopade OI, Woollatt E, Davies MJ, Segara D, Hacker NF, Henshall SM, Sutherland RL, Watts CK | title = EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer | journal = Oncogene | volume = 22 | issue = 32 | pages = 5070–81 | year = 2003 | pmid = 12902990 | doi = 10.1038/sj.onc.1206775 | s2cid = 25909437 | doi-access = }}
• {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional Proteomics Mapping of a Human Signaling Pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
• {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
• {{cite journal | vauthors = Kim JE, Tannenbaum SR, White FM | title = Global phosphoproteome of HT-29 human colon adenocarcinoma cells | journal = J. Proteome Res. | volume = 4 | issue = 4 | pages = 1339–46 | year = 2005 | pmid = 16083285 | doi = 10.1021/pr050048h }}
• {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
• {{cite journal | vauthors = Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK | title = EDD mediates DNA damage-induced activation of CHK2 | journal = J. Biol. Chem. | volume = 281 | issue = 52 | pages = 39990–40000 | year = 2007 | pmid = 17074762 | doi = 10.1074/jbc.M602818200 | s2cid = 25298222 | url = http://espace.library.uq.edu.au/view/UQ:192795/UQ192795_OA.pdf | doi-access = free }}
• {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
• {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}

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{{PDB Gallery|geneid=51366}}

• [http://www.signaling-gateway.org/molecule/query?afcsid=A004067 Ubr5 : Protein Overview : UCSD-Nature Molecule Pages]
• {{PDBe-KB2|O95071|E3 ubiquitin-protein ligase UBR5}}

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