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UGT2B17

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.{{cite journal | vauthors = Beaulieu M, Levesque E, Hum DW, Belanger A | title = Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids | journal = J Biol Chem | volume = 271 | issue = 37 | pages = 22855–62 |date=Nov 1996 | pmid = 8798464 | doi =10.1074/jbc.271.37.22855 | doi-access = free }}{{cite web | title = Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7367}}

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite{{cite journal |vauthors=Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P |title=Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms |journal=Cancer Research |volume=70 |issue=19 |pages=7543–52 |date=October 2010 |pmid=20876810 |pmc=2998997 |doi=10.1158/0008-5472.CAN-09-4582 |url= |issn=}}

References

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Further reading

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  • {{cite journal | vauthors=Chung LW, Coffey DS |title=Androgen glucuronide. II. Differences in its formation by human normal and benign hyperplastic prostates. |journal=Investigative Urology |volume=15 |issue= 5 |pages= 385–8 |year= 1978 |pmid= 76619 }}
  • {{cite journal | vauthors=Moghissi E, Ablan F, Horton R |title=Origin of plasma androstanediol glucuronide in men. |journal=J. Clin. Endocrinol. Metab. |volume=59 |issue= 3 |pages= 417–21 |year= 1984 |pmid= 6746859 |doi=10.1210/jcem-59-3-417 }}
  • {{cite journal |vauthors=Beaulieu M, Lévesque E, Tchernof A, etal |title=Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. |journal=DNA Cell Biol. |volume=16 |issue= 10 |pages= 1143–54 |year= 1997 |pmid= 9364925 |doi=10.1089/dna.1997.16.1143 }}
  • {{cite journal |vauthors=Collier AC, Ganley NA, Tingle MD, etal |title=UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term. |journal=Biochem. Pharmacol. |volume=63 |issue= 3 |pages= 409–19 |year= 2002 |pmid= 11853692 |doi=10.1016/S0006-2952(01)00890-5 }}
  • {{cite journal | vauthors=Chouinard S, Pelletier G, Bélanger A, Barbier O |s2cid=10971899 |title=Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. |journal=Endocr. Res. |volume=30 |issue= 4 |pages= 717–25 |year= 2005 |pmid= 15666817 |doi=10.1081/ERC-200044014 }}
  • {{cite journal |vauthors=Lazarus P, Zheng Y, Aaron Runkle E, etal |title=Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes. |journal=Pharmacogenet. Genomics |volume=15 |issue= 11 |pages= 769–78 |year= 2006 |pmid= 16220109 |doi=10.1097/01.fpc.0000175596.52443.ef |s2cid=10171438 }}
  • {{cite journal |vauthors=Jakobsson J, Ekström L, Inotsume N, etal |title=Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 2 |pages= 687–93 |year= 2006 |pmid= 16332934 |doi= 10.1210/jc.2005-1643 |doi-access= free }}
  • {{cite journal |vauthors=Park J, Chen L, Ratnashinge L, etal |title=Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 8 |pages= 1473–8 |year= 2006 |pmid= 16896035 |doi= 10.1158/1055-9965.EPI-06-0141 |doi-access= free }}
  • {{cite journal |vauthors=Gallagher CJ, Muscat JE, Hicks AN, etal |title=The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=16 |issue= 4 |pages= 823–8 |year= 2007 |pmid= 17416778 |doi= 10.1158/1055-9965.EPI-06-0823 |doi-access= free }}
  • {{cite journal |vauthors=Park JY, Tanner JP, Sellers TA, etal |title=Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk. |journal=Urology |volume=70 |issue= 2 |pages= 374–9 |year= 2007 |pmid= 17826523 |doi= 10.1016/j.urology.2007.03.001 }}
  • {{cite journal | vauthors=Chouinard S, Barbier O, Bélanger A |title=UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells. |journal=J. Biol. Chem. |volume=282 |issue= 46 |pages= 33466–74 |year= 2008 |pmid= 17848572 |doi= 10.1074/jbc.M703370200 |doi-access= free }}

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{{Glycosyltransferases}}

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