UGT8

Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney. The key enzymatic step in the biosynthesis of galactocerebrosides consists of the transfer of galactose to ceramide catalyzed by UDP-galactose ceramide galactosyltransferase (CGT, EC 2.4.1.45). The enzyme encoded by the CGT gene is the first involved in complex lipid biosynthesis in the myelinating oligodendrocyte.

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• {{cite journal | vauthors = Yahi N, Spitalnik SL, Stefano KA, De Micco P, Gonzalez-Scarano F, Fantini J | title = Interferon-gamma decreases cell surface expression of galactosyl ceramide, the receptor for HIV-1 GP120 on human colonic epithelial cells | journal = Virology | volume = 204 | issue = 2 | pages = 550–7 | year = 1994 | pmid = 7941321 | doi = 10.1006/viro.1994.1568 | doi-access = free }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Bhat S, Mettus RV, Reddy EP, Ugen KE, Srikanthan V, Williams WV, Weiner DB | title = The galactosyl ceramide/sulfatide receptor binding region of HIV-1 gp120 maps to amino acids 206-275 | journal = AIDS Res. Hum. Retroviruses | volume = 9 | issue = 2 | pages = 175–81 | year = 1993 | pmid = 8457384 | doi = 10.1089/aid.1993.9.175 }}
• {{cite journal | vauthors = Kapitonov D, Yu RK | title = Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA | journal = Biochem. Biophys. Res. Commun. | volume = 232 | issue = 2 | pages = 449–53 | year = 1997 | pmid = 9125199 | doi = 10.1006/bbrc.1997.6240 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Sprong H, Kruithof B, Leijendekker R, Slot JW, van Meer G, van der Sluijs P | title = UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 25880–8 | year = 1998 | pmid = 9748263 | doi = 10.1074/jbc.273.40.25880 | doi-access = free }}
• {{cite journal | vauthors = Iida A, Saito S, Sekine A, Mishima C, Kitamura Y, Kondo K, Harigae S, Osawa S, Nakamura Y | title = Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8 | journal = J. Hum. Genet. | volume = 47 | issue = 10 | pages = 505–10 | year = 2002 | pmid = 12376738 | doi = 10.1007/s100380200075 | doi-access = free }}
• {{cite journal | vauthors = Sprong H, Degroote S, Nilsson T, Kawakita M, Ishida N, van der Sluijs P, van Meer G | title = Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum | journal = Mol. Biol. Cell | volume = 14 | issue = 8 | pages = 3482–93 | year = 2003 | pmid = 12925779 | pmc = 181583 | doi = 10.1091/mbc.E03-03-0130 }}
• {{cite journal | vauthors = Tencomnao T, Kapitonov D, Bieberich E, Yu RK | title = Transcriptional regulation of the human UDP-galactose:ceramide galactosyltransferase (hCGT) gene expression: functional role of GC-box and CRE | journal = Glycoconj. J. | volume = 20 | issue = 5 | pages = 339–51 | year = 2004 | pmid = 15229398 | doi = 10.1023/B:GLYC.0000033630.58533.16 | s2cid = 38983312 }}

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{{Glycosyltransferases}}

{{Enzymes}}

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Category:EC 2.4.1

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