ULK2

{{infobox protein

| Name = unc-51-like kinase 2 (C. elegans)

| caption =

| image =

| width =

| HGNCid = 13480

| Symbol = ULK2

| AltSymbols =

| EntrezGene = 9706

| OMIM = 608650

| RefSeq = NM_014683

| UniProt = Q8IYT8

| PDB =

| ECnumber = 2.7.11.1

| Chromosome = 17

| Arm = p

| Band = 11.2

| LocusSupplementaryData =

}}

Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene.{{cite journal | vauthors = Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M | title = Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains | journal = Oncogene | volume = 18 | issue = 43 | pages = 5850–9 |date=October 1999 | pmid = 10557072 | doi = 10.1038/sj.onc.1202988 | doi-access = free }} The gene is located within the Smith–Magenis syndrome region on chromosome 17.

Structure and function

This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain.{{cite web | title = Entrez Gene: ULK2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9706}} ULK2 and the GTPase activating protein SynGAP function cooperatively in axon formation.{{cite journal | vauthors = Tomoda T, Kim JH, Zhan C, Hatten ME | title = Role of Unc51.1 and its binding partners in CNS axon outgrowth | journal = Genes Dev. | volume = 18 | issue = 5 | pages = 541–58 |date=March 2004 | pmid = 15014045 | pmc = 374236 | doi = 10.1101/gad.1151204 }}

References

External links

{{MeSH name|ULK2+protein,+mouse}}