UNC5A
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.{{cite web | title = Entrez Gene: UNC5A unc-5 homolog A (C. elegans)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90249| access-date = }}
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM]
Interactions
UNC5A has been shown to interact with MAGED1.{{cite journal | vauthors = Williams ME, Strickland P, Watanabe K, Hinck L | title = UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE | journal = The Journal of Biological Chemistry | volume = 278 | issue = 19 | pages = 17483–90 | date = May 2003 | pmid = 12598531 | doi = 10.1074/jbc.M300415200 | doi-access = free }}
References
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Further reading
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- {{cite journal | vauthors = Arakawa H | title = Netrin-1 and its receptors in tumorigenesis | journal = Nature Reviews. Cancer | volume = 4 | issue = 12 | pages = 978–87 | date = December 2004 | pmid = 15573119 | doi = 10.1038/nrc1504 | s2cid = 867903 }}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
- {{cite journal | vauthors = Nagase T, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins | journal = DNA Research | volume = 8 | issue = 6 | pages = 319–27 | date = December 2001 | pmid = 11853319 | doi = 10.1093/dnares/8.6.319 | doi-access = }}
- {{cite journal | vauthors = Williams ME, Strickland P, Watanabe K, Hinck L | title = UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE | journal = The Journal of Biological Chemistry | volume = 278 | issue = 19 | pages = 17483–90 | date = May 2003 | pmid = 12598531 | doi = 10.1074/jbc.M300415200 | doi-access = free }}
- {{cite journal | vauthors = Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H | title = p53RDL1 regulates p53-dependent apoptosis | journal = Nature Cell Biology | volume = 5 | issue = 3 | pages = 216–23 | date = March 2003 | pmid = 12598906 | doi = 10.1038/ncb943 | s2cid = 7017409 }}
- {{cite journal | vauthors = Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P | display-authors = 6 | title = The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 7 | pages = 4173–8 | date = April 2003 | pmid = 12655055 | pmc = 153067 | doi = 10.1073/pnas.0738063100 | bibcode = 2003PNAS..100.4173T | doi-access = free }}
- {{cite journal | vauthors = Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ | title = Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin | journal = The Journal of Biological Chemistry | volume = 278 | issue = 35 | pages = 32561–8 | date = August 2003 | pmid = 12810718 | doi = 10.1074/jbc.M302943200 | doi-access = free }}
- {{cite journal | vauthors = Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P | display-authors = 6 | title = The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase | journal = The EMBO Journal | volume = 24 | issue = 6 | pages = 1192–201 | date = March 2005 | pmid = 15729359 | pmc = 556396 | doi = 10.1038/sj.emboj.7600584 }}
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