USC

• Universidad del Sagrado Corazón, Santurce, Puerto Rico
• University of South Carolina, Columbia, South Carolina
• University of South Carolina System, a state university system of South Carolina
• University of Southern California, Los Angeles, California
• USC Trojans, the university's athletics team
• University of Southern Colorado, Pueblo, Colorado
• Upper St. Clair High School, Upper St. Clair, Pennsylvania
• Utica School of Commerce, a defunct business college in Utica, New York

• Shih Chien University, Taipei and Kaohsiung, Taiwan
• Sichuan University, Chengdu, Sichuan, China
• Ullapara Science College, Rajshahi Division, Bangladesh
• University of San Carlos, Cebu City, Philippines
• University of Santiago de Compostela, Santiago de Compostela, Spain
• University of Science and Culture, Tehran, Iran
• University Senior College, a year 11 and 12 school in Adelaide, South Australia
• University of South China, Hengyang, Hunan, China
• University of the Southern Caribbean, Maracas Valley, Trinidad and Tobago
• University of the Sunshine Coast, Queensland, Australia

• United Somali Congress (1987–2004), a former major rebel organization
• United States Code, the official code of United States federal law
• United States Congress, the law-making body of the United States government
• Universal Social Charge, an income tax in Ireland
• Utility Stores Corporation, a Pakistani state-owned store chain

• Ulster Special Constabulary, a former reserve police force in Northern Ireland
• United States Constabulary (1946–1952), the security force of the U.S. Occupation Zone of West Germany

• UEFA Super Cup, an annual association football super cup match
• United Soccer Coaches, a United States organization
• United SportsCar Championship, a racing series in the United States and Canada
• Unity Sporting Club, an association football (soccer) club in Wenchi, Ghana
• USC Lion Soccer Club, an association football (soccer) club in Adelaide, Australia, playing in the South Australian Amateur Soccer League

• USC (clothing retailer), a European clothing retailer with concessions inside Sports Direct stores
• USC Canada, a Unitarian development organization promoting agricultural biodiversity
• Heckler & Koch USC, a semiautomatic submachine gun
• Ubuntu Software Center, a discontinued software management system
• Uchinoura Space Center, a JAXA space vehicle launch facility
• Ulster Service Corps, loyalist vigilante group in Northern Ireland
• Unified Soil Classification System, used in engineering and geology
• United Shipbuilding Corporation, in Russia
• United States customary units, a system of measurement
• WWE United States Championship, a wrestling event

• Pontifical University of the Holy Cross, in Italy
• Unitarian Universalist Service Committee

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