USP10

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.

USP10 has been shown to interact with G3BP1.{{cite journal | vauthors = Soncini C, Berdo I, Draetta G | title = Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease | journal = Oncogene | volume = 20 | issue = 29 | pages = 3869–79 | date = June 2001 | pmid = 11439350 | doi = 10.1038/sj.onc.1204553 | s2cid = 7515868 | doi-access = free }}

In the endothelium, USP10 regulates Notch signaling by slowing down the degradation of the intracellular domain of NOTCH1. {{cite journal | vauthors = Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JW, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, Krüger M, Benedito R, Dikic I, Potente M | title = Deubiquitinase USP10 regulates Notch signaling in the endothelium. | journal = Science | volume = 364 | issue = 6436 | pages = 188–193 | date = April 2019 | pmid = 30975888 | doi = 10.1126/science.aat0778 |url=https://www.science.org/doi/abs/10.1126/science.aat0778| bibcode = 2019Sci...364..188L | hdl = 20.500.12105/9685 | s2cid = 109940358 | hdl-access = free }}

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