USP22

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17.{{cite web | title = Entrez Gene: Ubiquitin specific peptidase 22 | url = https://www.ncbi.nlm.nih.gov/gene/23326 }}

USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.{{cite web | url = https://www.uniprot.org/uniprot/Q9UPT9#section_comments | title = Q9UPT9 (UBP22_HUMAN) | work = UniProt }}

References

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Further reading

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  • {{cite journal | vauthors = Lang G, Bonnet J, Umlauf D, Karmodiya K, Koffler J, Stierle M, Devys D, Tora L | title = The tightly controlled deubiquitination activity of the human SAGA complex differentially modifies distinct gene regulatory elements | journal = Molecular and Cellular Biology | volume = 31 | issue = 18 | pages = 3734–44 | date = September 2011 | pmid = 21746879 | pmc = 3165722 | doi = 10.1128/MCB.05231-11 }}
  • {{cite journal | vauthors = Wang YL, Faiola F, Xu M, Pan S, Martinez E | title = Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein | journal = The Journal of Biological Chemistry | volume = 283 | issue = 49 | pages = 33808–15 | date = December 2008 | pmid = 18838386 | pmc = 2590711 | doi = 10.1074/jbc.M806936200 | doi-access = free }}
  • {{cite journal | vauthors = Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA | title = A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex | journal = Molecular and Cellular Biology | volume = 33 | issue = 8 | pages = 1487–502 | date = April 2013 | pmid = 23382074 | pmc = 3624249 | doi = 10.1128/MCB.00971-12 }}
  • {{cite journal | vauthors = Zhang Y, Yao L, Zhang X, Ji H, Wang L, Sun S, Pang D | title = Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer | journal = Journal of Cancer Research and Clinical Oncology | volume = 137 | issue = 8 | pages = 1245–53 | date = August 2011 | pmid = 21691749 | doi = 10.1007/s00432-011-0998-9 | s2cid = 9026376 }}
  • {{cite journal | vauthors = Ling SB, Sun DG, Tang B, Guo C, Zhang Y, Liang R, Wang LM | title = Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest | journal = Cellular and Molecular Biology | volume = 58 Suppl | pages = OL1803-8 | date = December 2012 | pmid = 23217440 }}
  • {{cite journal | vauthors = Xiong J, Che X, Li X, Yu H, Gong Z, Li W | title = Cloning and characterization of the human USP22 gene promoter | journal = PLOS ONE | volume = 7 | issue = 12 | pages = e52716 | year = 2012 | pmid = 23300749 | pmc = 3530469 | doi = 10.1371/journal.pone.0052716 | bibcode = 2012PLoSO...752716X | editor1-last = Semsey | editor1-first = Szabolcs | doi-access = free }}
  • {{cite journal | vauthors = Glinsky GV, Berezovska O, Glinskii AB | title = Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer | journal = The Journal of Clinical Investigation | volume = 115 | issue = 6 | pages = 1503–21 | date = June 2005 | pmid = 15931389 | pmc = 1136989 | doi = 10.1172/JCI23412 }}
  • {{cite journal | vauthors = Xu H, Liu YL, Yang YM, Dong XS | title = Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth | journal = International Journal of Colorectal Disease | volume = 27 | issue = 1 | pages = 21–30 | date = January 2012 | pmid = 21773699 | doi = 10.1007/s00384-011-1275-8 | s2cid = 25987858 }}
  • {{cite journal | vauthors = Liu YL, Yang YM, Xu H, Dong XS | title = Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer | journal = Journal of Surgical Oncology | volume = 103 | issue = 3 | pages = 283–9 | date = March 2011 | pmid = 21337558 | doi = 10.1002/jso.21802 | s2cid = 30706374 }}

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