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USP8

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.{{cite journal | vauthors = Puente XS, Sánchez LM, Overall CM, López-Otín C | title = Human and mouse proteases: a comparative genomic approach | journal = Nature Reviews. Genetics | volume = 4 | issue = 7 | pages = 544–58 | date = July 2003 | pmid = 12838346 | doi = 10.1038/nrg1111 | s2cid = 2856065 }}{{cite journal | vauthors = Janssen JW, Schleithoff L, Bartram CR, Schulz AS | title = An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme | journal = Oncogene | volume = 16 | issue = 13 | pages = 1767–72 | date = April 1998 | pmid = 9582025 | doi = 10.1038/sj.onc.1201695 | doi-access = free }}{{cite web | title = Entrez Gene: USP8 ubiquitin specific peptidase 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9101}}

Interactions

USP8 has been shown to interact with RNF41{{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7748–57 | date = September 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }} and STAM2.{{cite journal | vauthors = Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N | title = Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 48162–8 | date = November 2003 | pmid = 13129930 | doi = 10.1074/jbc.M306677200 | doi-access = free }}{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = December 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}

Diseases

In a few cases of Morbus Cushing's disease, a mutation of USP8 has been found.

References

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Further reading

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  • {{cite journal | vauthors = D'Andrea A, Pellman D | title = Deubiquitinating enzymes: a new class of biological regulators | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 33 | issue = 5 | pages = 337–52 | year = 1999 | pmid = 9827704 | doi = 10.1080/10409239891204251 }}
  • {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | display-authors = 6 | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 1 | issue = 5 | pages = 223–9 | year = 1995 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 | doi-access = free }}
  • {{cite journal | vauthors = Naviglio S, Mattecucci C, Matoskova B, Nagase T, Nomura N, Di Fiore PP, Draetta GF | title = UBPY: a growth-regulated human ubiquitin isopeptidase | journal = The EMBO Journal | volume = 17 | issue = 12 | pages = 3241–50 | date = June 1998 | pmid = 9628861 | pmc = 1170662 | doi = 10.1093/emboj/17.12.3241 }}
  • {{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = December 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 | doi-access = free }}
  • {{cite journal | vauthors = Gnesutta N, Ceriani M, Innocenti M, Mauri I, Zippel R, Sturani E, Borgonovo B, Berruti G, Martegani E | display-authors = 6 | title = Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 42 | pages = 39448–54 | date = October 2001 | pmid = 11500497 | doi = 10.1074/jbc.M103454200 | doi-access = free | hdl = 2434/28853 | hdl-access = free }}
  • {{cite journal | vauthors = Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N | title = Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 48162–8 | date = November 2003 | pmid = 13129930 | doi = 10.1074/jbc.M306677200 | doi-access = free }}
  • {{cite journal | vauthors = Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG | display-authors = 6 | title = Two isoforms of otubain 1 regulate T cell anergy via GRAIL | journal = Nature Immunology | volume = 5 | issue = 1 | pages = 45–54 | date = January 2004 | pmid = 14661020 | doi = 10.1038/ni1017 | s2cid = 27005972 }}
  • {{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7748–57 | date = September 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }}
  • {{cite journal | vauthors = Berruti G, Martegani E | title = The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1: the relation with the proteasome, acrosome, and centrosome in mouse male germ cells | journal = Biology of Reproduction | volume = 72 | issue = 1 | pages = 14–21 | date = January 2005 | pmid = 15342353 | doi = 10.1095/biolreprod.104.030866 | doi-access = free }}
  • {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Molecular & Cellular Proteomics | volume = 4 | issue = 6 | pages = 785–95 | date = June 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 | doi-access = free }}
  • {{cite journal | vauthors = Row PE, Prior IA, McCullough J, Clague MJ, Urbé S | title = The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation | journal = The Journal of Biological Chemistry | volume = 281 | issue = 18 | pages = 12618–24 | date = May 2006 | pmid = 16520378 | doi = 10.1074/jbc.M512615200 | doi-access = free }}
  • {{cite journal | vauthors = Mizuno E, Kobayashi K, Yamamoto A, Kitamura N, Komada M | title = A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes | journal = Traffic | volume = 7 | issue = 8 | pages = 1017–31 | date = August 2006 | pmid = 16771824 | doi = 10.1111/j.1600-0854.2006.00452.x | doi-access = free }}
  • {{cite journal | vauthors = Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S | title = Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8) | journal = The Journal of Biological Chemistry | volume = 281 | issue = 49 | pages = 38061–70 | date = December 2006 | pmid = 17035239 | doi = 10.1074/jbc.M606704200 | doi-access = free }}

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