User:Judenicholson
{{chembox
| ImageFile = Nutlin3.PNG
| ImageSize =
| IUPACName = (±)-4-[4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one Nutlin-3
| OtherNames = Nutlin
| Section1 = {{Chembox Identifiers
| CASNo = 675576-98-4
| CASNo_Ref = {{cascite|correct|CAS}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = L7C92IOE65
| PubChem = 16755649
| SMILES = CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl canonical
}}
| Section2 = {{Chembox Properties
| Formula = C30H30Cl2N4O4
| MolarMass = 581.4896 [g/mol]
| Appearance =
| Density =
| MeltingPt =
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}}
| Section3 = {{Chembox Hazards
| MainHazards =
| FlashPt =
| Autoignition =
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Nutlins are cis-imidazoline analogs which inhibit the interaction between MDM2 and p53, and were discovered by screening a chemical library by Vassiliev et al. Nutlin-1, Nutlin-2 and Nutlin-3 were all identified in the same screen,{{cite journal |author = Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, Kong N, Kammlott U, Lukacs C, Klein C, Fotouhi N, Liu EA |title = In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 |journal=Science |volume=6 |issue= |pages= 844-848 |year= 2004 |pmid= 14704432 |doi=}} however Nutlin-3 is the compound most commonly used in anti-cancer studies.{{cite journal |author = Shangary S, Wang S. |title = Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy |journal = Annu Rev Pharmacol Toxicol. |volume = |issue = | pages = |year = 2008 |pmid = 18834305 |doi= }}
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