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Fudosteine

Fudosteine ((-)-(R)-2-amino-3-(3-hydroxypropylthio)propionic acid)is a novel mucoactive agent, although little is known about how fudosteine decreases mucin production.

Physicochemical properties of the active ingredient:

Generic name: Fudosutein

Common Name : fudosteine

Chemical Name: (-)-( R)-2-amino-3-(3-hydroxypropylthio) propionic acid

Molecular formula: C 6 H 13 NO 3 S

Molecular Weight: 179.24

Melting point: 200 approx (decomposition)

Physical properties: white crystal or crystalline powder, Very soluble in formic acid, freely soluble in water, acetic acid (100), less soluble in ethanol (95), very insoluble, practically insoluble in diethyl ether.

References

primary literature

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中道 昇他, 臨床医薬 , 18 (1), 45, (2002) »J-GLOBAL Other Nakamiti Noboru, clinical medicine, 18 (a), 45, (two thousand and two) »J-GLOBAL

木暮敏博他, 薬物動態 , 12 (5), 491, (1997) »J-STAGE »J-GLOBAL Kogure Toshihiro others, pharmacokinetics, 12 (5), four hundred and ninety-one, (one thousand nine hundred ninety-seven) »J-STAGE »J-GLOBAL

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長岡 滋他, 臨床医薬 , 18 (1), 181, (2002) »J-GLOBAL Nagaoka Shigeru others, clinical medicine, 18 (a), 181, (2,002) »J-GLOBAL

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高橋光一他, Jpn.J.Pharmacol , 77 (1), 71, (1998) »PubMed Takahashi Kouiti others, Jpn.j.pharmacol, seventy-seven (1), seventy-one, (one thousand nine hundred ninety-eight) »PubMed

高橋光一他, Environ.Toxicol.Pharmacol , 5 , 173, (1998) Takahashi Kouiti others, Environ.Toxicol.Pharmacol, 5, 173, (1998