User talk:Meodipt#List of opioids

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first, the boiler-plate welcome:

Welcome!

Hello, {{PAGENAME}}, and welcome to Wikipedia! Thank you for your contributions. I hope you like the place and decide to stay. Here are a few good links for newcomers:

I hope you enjoy editing here and being a Wikipedian! Please sign your name on talk pages using four tildes (~~~~); this will automatically produce your name and the date. If you need help, check out Wikipedia:Questions, ask me on my talk page, or place {{helpme}} on your talk page and someone will show up shortly to answer your questions. Again, welcome!

i'd also like to extend an invitation to the WikiProject on Psychedelics, Dissociatives and Deliriants. Which isn't invitation only or anything, i just thought that you might be interested in checking it out.

welcome again, hope you enjoy editing here!

Anti-aging claims

Medodipt - on my talk page, you said: "My main reason for adding pterostilbene to the "Anti-aging substances" category is that resveratrol is listed in this category, and pterostilbene is essentially identical in activity to resveratrol but with higher bioavailability. I refer you for instance to the following recent review articles; {{pmid|23808710}} {{pmid|29168580}} {{pmid|29210129}} {{pmid|37979699}}. When I have time I may add a paragraph to the article citing these in support of this claim."

None of those sources qualifies as a valid source for health-related claims, as based on WP:MEDASSESS, top of left pyramid. Those sources are just exaggerated speculation extended from early-stage lab research, then published in low-quality, non-clinical and non-WP:MEDRS journals. Neither resveratrol nor pterostilbene has adequate clinical evidence to support an anti-aging or any health claim.

If there was adequate anti-aging evidence, there would be 1) a major systematic review in journals like The Lancet or New England Journal of Medicine, 2) a biotech drug candidate having completed rigorous Phase III trials with evidence of safety and efficacy, 3) a government (e.g., FDA) advisory for the public to consume more pterostilbene or resveratrol, or 4) national clinical organizations with dietary guidelines discussing #1-3.

None of these exist, despite 3+ decades of lab research. [https://consumer.ftc.gov/sites/default/files/articles/pdf/pdf-0112-miracle-health-claims-and-dietary-supplements.pdf Take a dose of skepticism.] Zefr (talk) 04:21, 24 January 2025 (UTC)

File:Olomorasib structure.png

Hi, for :commons:File:Olomorasib structure.png on commons there is an error. The ring that contains nitrogen and oxygen actually has 8 atoms in it. There should be an extra carbon adjacent to the oxygen. It confused me as to whether Olomorasib was an oxazocine or oxazopine! cf the pubchem diagram. I hope you can fix it up! Graeme Bartlett (talk) 07:46, 6 March 2025 (UTC)

: Oh dear yes will fix that. Teach me for trying to whip out a quick wiki page before work! Meodipt (talk) 08:12, 6 March 2025 (UTC)

about [[2C-T-21.5]]

also known as 4-(2,2-difluoroethylthio)-2,5-dimethoxyphenethylamine, C12H17F2NO2S

but PubChem CID 168072172: 2-[4-(3,3-Difluoropropylsulfanyl)-2,5-dimethoxyphenyl]ethanamine, C13H19F2NO2S,

so i corrected it. Htmlzycq (talk) 07:34, 18 April 2025 (UTC)

: Thanks for spotting that, have added the link to the correct PubChem page instead. Meodipt (talk) 21:48, 18 April 2025 (UTC)

PR-608 draft

I recently discovered an agent called PR-608 and decided to make a draft for this compound on wikipedia:

https://en.wikipedia.org/wiki/Draft:PR-608

Please could you help me with submitting this draft as I am having difficulty getting it accepted.92.31.192.97 (talk) 09:00, 27 April 2025 (UTC)

: Looking at that reviewer's last 500 edits, they have accepted only 4 draft articles for creation, and declined over 100. So I'm afraid you just came across a very conservative reviewer and your page had no chance of being accepted! It looks ok to me, maybe just talk about it strictly as a pharmacological tool compound and don't suggest potential medical uses. PubChem shows one additional reference you haven't included (PMID:15261288) but there is not much more to say about it. No research since 2004 anyway, these bisarylalkylpiperazines aren't very interesting compounds for the most part, they inhibit dopamine release nearly as much as reuptake and do not produce stimulant effects, and have failed as antidepressants, anti-Parkinsonians and substitute drugs for amphetamine abuse. Just try re-word it focusing on applications for in vitro research and resubmit I guess, and hope the next reviewer is more favorably disposed to this kind of page. Meodipt (talk) 19:43, 27 April 2025 (UTC)

[[North-methanocarbathymidine]]

You're the creator of this article so I am wondering if you could find an appropriate place to link to this article so that it isn't an orphan article? Velayinosu (talk) 00:15, 30 April 2025 (UTC)

: I would suggest just adding the antivirals template to the bottom and then adding it to that template as a miscellaneous antiviral drug not accepted for medical use. All these old antivirals keep getting recycled whenever a new viral epidemic comes along, I created most of these pages either during the Ebola epidemic(s) in West Africa or the Covid pandemic, and there is a reasonable chance any given compound could suddenly become very significant if it turns out to be the most effective thing available for some novel zoonotic viral disease that has popped up. Meodipt (talk) 06:01, 30 April 2025 (UTC)