Uterine inversion

{{redirect|Inverted uterus|a different orientation of the uterus|retroverted uterus}}

{{Infobox medical condition (new)

| name = {{PAGENAME}}

| synonyms =

| image = InvertedUterus.jpg

| width =

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| caption = Complete inverted uterus

| pronounce =

| field = Obstetrics

| symptoms = Postpartum bleeding, abdominal pain, mass in the vagina, low blood pressure

| complications =

| onset =

| duration =

| types = First, second, third, fourth degree

| causes =

| risks = Pulling on the umbilical cord or pushing on the top of the uterus before the placenta has detached, uterine atony, placenta previa, connective tissue disorders

| diagnosis = Seeing the inside of the uterus in the vagina

| differential = Uterine fibroid, uterine atony, bleeding disorder, retained placenta

| prevention =

| treatment = Standard resuscitation, rapidly replacing the uterus

| medication = Oxytocin, antibiotics

| prognosis = ~15% risk of death

| frequency = About 1 in 6,000 deliveries

| deaths =

}}

Uterine inversion is when the uterus turns inside out, usually following childbirth.{{cite journal |last1=Bhalla |first1=Rita |last2=Wuntakal |first2=Rekha |last3=Odejinmi |first3=Funlayo |last4=Khan |first4=Rehan U |title=Acute inversion of the uterus |journal=The Obstetrician & Gynaecologist |date=January 2009 |volume=11 |issue=1 |pages=13–18 |doi=10.1576/toag.11.1.13.27463|s2cid=116580372 |doi-access= }} Symptoms include postpartum bleeding, abdominal pain, a mass in the vagina, and low blood pressure. Rarely inversion may occur not in association with pregnancy.{{cite journal |last1=Mehra |first1=R |last2=Siwatch |first2=S |last3=Arora |first3=S |last4=Kundu |first4=R |title=Non-puerperal uterine inversion caused by malignant mixed mullerian sarcoma. |journal=BMJ Case Reports |date=12 December 2013 |volume=2013 |pages=bcr2013200578 |doi=10.1136/bcr-2013-200578 |pmid=24334469|pmc=3863018 }}

Risk factors include pulling on the umbilical cord or pushing on the top of the uterus before the placenta has detached. Other risk factors include uterine atony, placenta previa, and connective tissue disorders. Diagnosis is by seeing the inside of the uterus either in or coming out of the vagina.{{cite journal |last1=Mirza |first1=FG |last2=Gaddipati |first2=S |title=Obstetric emergencies. |journal=Seminars in Perinatology |date=April 2009 |volume=33 |issue=2 |pages=97–103 |doi=10.1053/j.semperi.2009.01.003 |pmid=19324238}}{{cite book |last1=Apuzzio |first1=Joseph J. |last2=Vintzileos |first2=Anthony M. |last3=Berghella |first3=Vincenzo |last4=Alvarez-Perez |first4=Jesus R. |title=Operative Obstetrics, 4E |date=2017 |publisher=CRC Press |isbn=9781498720588 |page=PT822 |url=https://books.google.com/books?id=JLzZDQAAQBAJ&pg=PT822 |language=en}}

Treatment involves standard resuscitation together with replacing the uterus as rapidly as possible. If efforts at manual replacement are not successful surgery is required. After the uterus is replaced oxytocin and antibiotics are typically recommended. The placenta can then be removed if it is still attached.

Uterine inversion occurs in about 1 in 2,000 to 1 in 10,000 deliveries.{{cite journal |last1=Andersen |first1=H. Frank |last2=Hopkins |first2=Michael P. |title=Postpartum Hemorrhage |journal=The Global Library of Women's Medicine |date=2009 |doi=10.3843/GLOWM.10138}} Rates are higher in the developing world. The risk of death of the mother is about 15% while historically it has been as high as 80%.{{cite book |last1=Gandhi |first1=Alpesh |last2=Malhotra |first2=Narendra |last3=Malhotra |first3=Jaideep |last4=Gupta |first4=Nidhi |last5=Bora |first5=Neharika Malhotra |title=Principles of Critical Care in Obstetrics |date=2016 |publisher=Springer |isbn=9788132226925 |page=335 |url=https://books.google.com/books?id=nf2uCwAAQBAJ&pg=PA335 |language=en}} The condition has been described since at least 300 BC by Hippocrates.