Login
Login

VNN1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Pantetheinase is an enzyme that in humans is encoded by the VNN1 gene.{{cite journal | vauthors = Galland F, Malergue F, Bazin H, Mattei MG, Aurrand-Lions M, Theillet C, Naquet P | title = Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6 | journal = Genomics | volume = 53 | issue = 2 | pages = 203–13 |date=Dec 1998 | pmid = 9790769 | doi = 10.1006/geno.1998.5481 }}{{cite web | title = Entrez Gene: VNN1 vanin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8876}}

This gene product is a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal |vauthors=Aurrand-Lions M, Galland F, Bazin H, etal |title=Vanin-1, a novel GPI-linked perivascular molecule involved in thymus homing. |journal=Immunity |volume=5 |issue= 5 |pages= 391–405 |year= 1997 |pmid= 8934567 |doi=10.1016/S1074-7613(00)80496-3 |doi-access=free }}
  • {{cite journal | vauthors=Maras B, Barra D, Dupré S, Pitari G |title=Is pantetheinase the actual identity of mouse and human vanin-1 proteins? |journal=FEBS Lett. |volume=461 |issue= 3 |pages= 149–52 |year= 1999 |pmid= 10567687 |doi=10.1016/S0014-5793(99)01439-8 |s2cid=25738323 |doi-access= }}
  • {{cite journal |vauthors=Martin F, Malergue F, Pitari G, etal |title=Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 296–306 |year= 2001 |pmid= 11491533 |doi=10.1007/s002510100327 |s2cid=10763223 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |bibcode=2003Natur.425..805M |doi-access= free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Kristiansen TZ, Bunkenborg J, Gronborg M, etal |title=A proteomic analysis of human bile. |journal=Mol. Cell. Proteomics |volume=3 |issue= 7 |pages= 715–28 |year= 2005 |pmid= 15084671 |doi= 10.1074/mcp.M400015-MCP200 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Liu T, Qian WJ, Gritsenko MA, etal |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 | pmc=1850943 }}
  • {{cite journal |vauthors=Min-Oo G, Fortin A, Pitari G, etal |title=Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. |journal=J. Exp. Med. |volume=204 |issue= 3 |pages= 511–24 |year= 2007 |pmid= 17312006 |doi= 10.1084/jem.20061252 | pmc=2137903 }}

{{refend}}

{{gene-6-stub}}