VTCN1

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]

B7-H4 is an immune checkpoint molecule.

• B7 (protein)

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• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM | title = BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 | journal = Nature Immunology | volume = 4 | issue = 7 | pages = 670–9 | date = July 2003 | pmid = 12796776 | doi = 10.1038/ni944 | s2cid = 11943145 }}
• {{cite journal | vauthors = Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP | title = B7x: a widely expressed B7 family member that inhibits T cell activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10388–92 | date = September 2003 | pmid = 12920180 | pmc = 193571 | doi = 10.1073/pnas.1434299100 | bibcode = 2003PNAS..10010388Z | doi-access = free }}
• {{cite journal | vauthors = Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L | title = Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family | journal = Journal of Immunology | volume = 171 | issue = 9 | pages = 4650–4 | date = November 2003 | pmid = 14568939 | doi = 10.4049/jimmunol.171.9.4650 | doi-access = free }}
• {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 | s2cid = 27764390 }}
• {{cite journal | vauthors = Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, Liu W, Pilkington G, Papkoff J | title = The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation | journal = Experimental Cell Research | volume = 306 | issue = 1 | pages = 128–41 | date = May 2005 | pmid = 15878339 | doi = 10.1016/j.yexcr.2005.01.018 }}
• {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
• {{cite journal | vauthors = Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W | title = B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma | journal = The Journal of Experimental Medicine | volume = 203 | issue = 4 | pages = 871–81 | date = April 2006 | pmid = 16606666 | pmc = 2118300 | doi = 10.1084/jem.20050930 }}
• {{cite journal | vauthors = Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W | title = Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells | journal = Journal of Immunology | volume = 177 | issue = 1 | pages = 40–4 | date = July 2006 | doi = 10.4049/jimmunol.177.1.40 | pmid = 16785496 | s2cid = 922578 | doi-access = free }}
• {{cite journal | vauthors = Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED | title = B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 27 | pages = 10391–6 | date = July 2006 | pmid = 16798883 | pmc = 1502468 | doi = 10.1073/pnas.0600937103 | bibcode = 2006PNAS..10310391K | doi-access = free }}
• {{cite journal | vauthors = Chen Y, Yang C, Xie Z, Zou L, Ruan Z, Zhang X, Tang Y, Fei L, Jia Z, Wu Y | title = Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells | journal = Kidney International | volume = 70 | issue = 12 | pages = 2092–9 | date = December 2006 | pmid = 17051145 | doi = 10.1038/sj.ki.5001867 | doi-access = free }}
• {{cite journal | vauthors = Simon I, Katsaros D, Rigault de la Longrais I, Massobrio M, Scorilas A, Kim NW, Sarno MJ, Wolfert RL, Diamandis EP | title = B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression | journal = Gynecologic Oncology | volume = 106 | issue = 2 | pages = 334–41 | date = August 2007 | pmid = 17498784 | doi = 10.1016/j.ygyno.2007.03.035 }}
• {{cite journal | vauthors = Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR | title = B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration | journal = Gynecologic Oncology | volume = 106 | issue = 1 | pages = 119–27 | date = July 2007 | pmid = 17509674 | doi = 10.1016/j.ygyno.2007.03.039 }}

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{{B7 family}}

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