Vaporized hydrogen peroxide
{{Short description|Vapor form of hydrogen peroxide}}
Vaporized hydrogen peroxide (trademarked VHP,{{cite web|url=http://www.sterislifesciences.com/Products/Equipment/VHP.aspx|title=VHP (Vaporized Hydrogen Peroxide) Biodecontamination Systems|publisher=sterislifesciences.com}} Retrieved February 2016. also known as hydrogen peroxide vapor, HPV) is a vapor form of hydrogen peroxide (H2O2) with applications as a low-temperature antimicrobial vapor used to decontaminate enclosed and sealed areas such as laboratory workstations, isolation and pass-through rooms,{{cite web|url=http://www.epa.gov/webmast1/nlconversion_0421/test/opp/vhp_factsheet.htm|title=EPA: Pesticides - Vaporized Hydrogen Peroxide|publisher=US Environmental Protection Agency|archive-url=https://web.archive.org/web/20061010185623/http://www.epa.gov/pesticides/factsheets/chemicals/vhp_factsheet.htm|archive-date=October 10, 2006}} and even aircraft interiors.{{cite web|url=http://stinet.dtic.mil/cgi-bin/GetTRDoc?AD=ADA460897&Location=U2&doc=GetTRDoc.pdf|archive-url=https://web.archive.org/web/20120225070544/http://stinet.dtic.mil/cgi-bin/GetTRDoc?AD=ADA460897&Location=U2&doc=GetTRDoc.pdf|url-status=dead|archive-date=February 25, 2012|title=Vaporized Hydrogen peroxide (VHP) Decontamination if a Section of a Boeing 747 Cabin|publisher=US Federal Aviation Administration}} Retrieved September 2008.
Use as sterilant
=Regulatory status=
VHP is registered by the U.S. Environmental Protection Agency as a sterilant, which the EPA defines as "a substance that destroys or eliminates all forms of microbial life in the inanimate environment, including all forms of vegetative bacteria, bacterial spores, fungi, fungal spores, and viruses". As a sterilant, VHP is one of the chemicals approved for decontamination of anthrax spores from contaminated buildings, such as occurred during the 2001 anthrax attacks in the U.S.{{cite web|url=http://www.epa.gov/pesticides/factsheets/chemicals/vhp_factsheet.htm|title=Anthrax Spore Decontamination using Hydrogen Peroxide Vapor|publisher=US Environmental Protection Agency}} Retrieved September 2008. It has also been shown to be effective in removing exotic animal viruses, such as avian influenza and Newcastle disease from equipment and surfaces.{{cite journal|url=http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=168702&blobtype=pdf|title=Efficacy of Vaporized Hydrogen Peroxide against Exotic Animal Viruses|publisher=US National Institutes of Health|pmc=168702|pmid=9327555|volume=63|issue=10|journal=Appl Environ Microbiol|pages=3916–8 | last1 = Heckert | first1 = RA | last2 = Best | first2 = M | last3 = Jordan | first3 = LT | last4 = Dulac | first4 = GC | last5 = Eddington | first5 = DL | last6 = Sterritt | first6 = WG|year=1997|doi=10.1128/AEM.63.10.3916-3918.1997|bibcode=1997ApEnM..63.3916H }} Retrieved September 2008.
=Application=
VHP is produced from a solution of liquid H2O2 and water, by generators specifically designed for the purpose. These generators initially dehumidify the ambient air, then produce VHP by passing aqueous hydrogen peroxide over a vaporizer, and circulate the vapor at a programmed concentration in the air, typically from 140 ppm to 1400 ppm, depending on the infectious agent to be cleared.{{cite web|url=http://www.phoenixcontrols.com/documents/HPV%20White%20Paper%20(MKT-0169).pdf|title=HVAC Considerations for Gaseous Decontamination of Laboratory Spaces using Hydrogen Peroxide Vapor (HPV)|publisher=Phoenix Controls Corporation}} Retrieved September 2008. By comparison, a concentration of 75 ppm is considered to be "Immediately Dangerous to Life or Health" in humans.{{cite web|url=https://www.cdc.gov/niosh/idlh/intridl4.html|title=NIOSH:Documentation for Immediately Dangerous to Life or Health Concentrations|date=26 February 2021 |publisher=US Centers for Disease Control}} Retrieved September 2008. After the VHP has circulated in the enclosed space for a pre-defined period, it is circulated back through the generator, where it is broken down into water and oxygen by a catalytic converter until concentrations of VHP fall to safe levels (typically <1 ppm). Alternatively, the VHP is vented to the outside air, in cases where recapturing of the VHP is not needed.
=Use in hospitals=
Vaporized hydrogen peroxide has been investigated as an airborne disinfectant and infection control measure for hospitals{{cite journal|last1=Falagas|first1=M.E.|last2=Thomaidis|first2=P.C.|last3=Kotsantis|first3=I.K.|last4=Sgouros|first4=K.|last5=Samonis|first5=G.|last6=Karageorgopoulos|first6=D.E.|title=Airborne hydrogen peroxide for disinfection of the hospital environment and infection control: a systematic review|journal=Journal of Hospital Infection|date=July 2011|volume=78|issue=3|pages=171–177|doi=10.1016/j.jhin.2010.12.006|pmid=21392848}} and has been shown to reduce incidence of nosocomial infections from several pathogens. Clostridioides difficile associated disease, VRE and MRSA are all associated with environmental contamination. H2O2 vapor has been used in hospitals to eradicate causal agents, e.g., antibiotic-resistant Klebsiella pneumoniae, from the environment and prevent infection of subsequent patients.Vastag, Brian (2012), "Deadly Bacteria Stalked Hospital", The Washington Post, Thursday, 23 August 2012, pg A1.
= Monitoring technologies =
OSHA mandates a PEL of 1.0 ppm (1.4 mg/m ) for HPV.{{Cite web|url=https://www.osha.gov/dts/sltc/methods/validated/1019/1019.pdf|title=Hydrogen Peroxide - OSHA Analytical Method 1019|website=osha.gov|date=January 2016|access-date=2019-01-03}} Typically, safe working environments around sterilization equipment is achieved with electrochemical sensors capable of measuring in the parts per billion and low parts per million levels. These sensors are typically inexpensive and limited to ambient conditions. Moreover, HPV electrochemical sensors are often located near the sterilization equipment to detect possible leaks during the sterilization cycle. In 2014, Advanced Sterilization Products (ASP), sovaldi the manufacturer of the Sterrad hydrogen peroxide gas plasma sterilizer, issued a letter to hospital risk managers warning them that hydrogen peroxide residues may be found in the sterilization load.{{Cite web|url=http://www.chemdaq.com/asp-warns-of-exposure-to-residual-hydrogen-peroxide-in-sterilizer-load/ |title=ASP Warns of Exposure to Residual Hydrogen Peroxide in Sterilizer Load |date=2014-01-20 |publisher=ChemDAQ |archive-url=https://web.archive.org/web/20190412221028/http://www.chemdaq.com/asp-warns-of-exposure-to-residual-hydrogen-peroxide-in-sterilizer-load/ |archive-date=2019-04-12 |url-status=dead}} HPV being present in the sterilization load, could lead the accidental exposure of hospital staff.
Monitoring hydrogen peroxide levels inside the sterilization chamber during the sterilization cycle can be challenging. Technical issues such as condensation, vacuum, and high concentration have prevented many sensing technologies such as electrochemical sensors from providing real-time monitoring of H2O2 concentration. Under these conditions, optical methods such as spectroscopy{{Cite web|title=Hydrogen Peroxide Vapor (HPV) Analyzer System Measuring {{chem|H|2|O|2}} and {{chem|H|2|O}} Under Ambient or Vacuum Conditions|url=https://guided-wave.com/hydrogen-peroxide-vapor-hpv-analyzer-system/|access-date=}} can be used to ensure that lethal concentrations of H2O2 are achieved in the sterilization chamber.
Dangers of manipulation
Hydrogen peroxide vapors and fumes can irritate and damage the skin, the respiratory tract, and the eyes. Extreme precautions must be taken when manipulating hydrogen peroxide, and it must not be considered harmless.