Vasicine

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| ImageFile = Vasicin.svg

| ImageSize = 200px

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| IUPACName = (3S)-1,2,3,9-Tetrahydropyrrolo[2,1-b]quinazolin-3-ol

| OtherNames = Peganine; (-)-vasicine

|Section1={{Chembox Identifiers

| index1_label = (±)

| CASNo = 6159-55-3

| CASNo1 = 6159-56-4

| CASNo_Ref = {{cascite|correct|CAS}}

| UNII_Ref = {{fdacite|correct|FDA}}

| UNII = 6C2ZBI733P

| PubChem = 667496

| SMILES = O[C@@H]1C=2N(CC=3C(N2)=CC=CC3)CC1}}

|Section2={{Chembox Properties

| C=11 | H=12 | N=2 | O=1

| Appearance =

| Density =

| MeltingPtC = 210

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| SolubleOther = Soluble

| Solvent = acetone, alcohol, chloroform}}

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Vasicine (peganine) is a quinazoline alkaloid. It is found in Justicia adhatoda, after which it is named. It is additionally found in Peganum harmala.{{cite journal |vauthors=Moloudizargari M, Mikaili P, Aghajanshakeri S, Asghari MH, Shayegh J |title=Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids |journal=Pharmacogn Rev |volume=7 |issue=14 |pages=199–212 |date=July 2013 |pmid=24347928 |pmc=3841998 |doi=10.4103/0973-7847.120524 |doi-access=free }}

Vasicine has been compared to theophylline both in vitro and in vivo.{{cite journal|last1=Nepali|first1=Kunal|last2=Sharma|first2=Sahil| last3=Ojha|first3=Ritu| last4=Dhar|first4=Kanaya Lal| title=Vasicine and structurally related quinazolines|journal=Medicinal Chemistry Research| volume=22|issue=1| year=2012|pages=1–15|issn=1054-2523|doi=10.1007/s00044-012-0002-5|s2cid=253636554 }} It has also been studied in combination with the related alkaloid vasicinone. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro.{{cite journal| last=Avula | first=B. | title=Quantitative determination of vasicine and vasicinone in Adhatoda vasica by high performance capillary electrophoresis | journal=Die Pharmazie | volume=63 | issue=1 | year=2008 | pages=20–22 | doi=10.1691/ph.2008.7175 | pmid=18271297 | url=http://docserver.ingentaconnect.com/deliver/connect/govi/00317144/v63n1/s4.pdf?expires=1388798104&id=76777466&titleid=75007325 |display-authors=etal}} Both alkaloids are also respiratory stimulants. Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids.{{cite journal|last1=Rajani|first1=M|last2=Soni|first2=S|last3=Anandjiwala|first3=Sheetal|last4=Patel|first4=G|title=Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine|journal=Indian Journal of Pharmaceutical Sciences|volume=70|issue=1|year=2008|pages=36–42|issn=0250-474X|doi=10.4103/0250-474X.40329|pmid=20390078|pmc=2852058|doi-access=free}} Vasicine is reported to have a uterine stimulant effect.