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WDR3

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{About||the German radio station|Westdeutscher Rundfunk}}

{{Infobox_gene}}

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.{{cite journal |vauthors=Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG | title = Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13 | journal = Genomics | volume = 59 | issue = 1 | pages = 85–9 |date=Aug 1999 | pmid = 10395803 | doi = 10.1006/geno.1999.5858 }}{{cite web | title = Entrez Gene: WDR3 WD repeat domain 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10885}}

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

References

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Further reading

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  • {{cite journal |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |doi-access=free }}
  • {{cite journal |vauthors=Andersen JS, Lam YW, Leung AK, etal |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |bibcode=2005Natur.433...77A |s2cid=4344740 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Scherl A, Couté Y, Déon C, etal |title=Functional proteomic analysis of human nucleolus |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100–9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 | pmc=133617 }}
  • {{cite journal |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |s2cid=14132033 |doi-access=free }}
  • {{cite journal |vauthors=Claudio JO, Liew CC, Dempsey AA, etal |title=Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy |journal=Genomics |volume=50 |issue= 1 |pages= 44–52 |year= 1999 |pmid= 9628821 |doi= 10.1006/geno.1998.5308 }}

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Category:Genes mutated in mice

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